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000272873 1001_ $$0P:(DE-2719)9002936$$aShirvani Samani, Omid$$b0$$eFirst author$$udzne
000272873 245__ $$aMachine learning models for outcome prediction in thrombectomy for large anterior vessel occlusion.
000272873 260__ $$aChichester [u.a.]$$bWiley$$c2024
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000272873 520__ $$aPredicting long-term functional outcomes shortly after a stroke is challenging, even for experienced neurologists. Therefore, we aimed to evaluate multiple machine learning models and the importance of clinical/radiological parameters to develop a model that balances minimal input data with reliable predictions of long-term functional independency.Our study utilized data from the German Stroke Registry on patients with large anterior vessel occlusion who underwent endovascular treatment. We trained seven machine learning models using 30 parameters from the first day postadmission to predict a modified Ranking Scale of 0-2 at 90 days poststroke. Model performance was assessed using a 20-fold cross-validation and one-sided Wilcoxon rank-sum tests. Key features were identified through backward feature selection.We included 7485 individuals with a median age of 75 years and a median NIHSS score at admission of 14 in our analysis. Our Deep Neural Network model demonstrated the best performance among all models including data from 24 h postadmission. Backward feature selection identified the seven most important features to be NIHSS after 24 h, age, modified Ranking Scale after 24 h, premorbid modified Ranking Scale, intracranial hemorrhage within 24 h, intravenous thrombolysis, and NIHSS at admission. Narrowing the Deep Neural Network model's input data to these features preserved the high performance with an AUC of 0.9 (CI: 0.89-0.91).Our Deep Neural Network model, trained on over 7000 patients, predicts 90-day functional independence using only seven clinical/radiological features from the first day postadmission, demonstrating both high accuracy and practicality for clinical implementation on stroke units.
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000272873 650_2 $$2MeSH$$aHumans
000272873 650_2 $$2MeSH$$aAged
000272873 650_2 $$2MeSH$$aMale
000272873 650_2 $$2MeSH$$aFemale
000272873 650_2 $$2MeSH$$aMachine Learning
000272873 650_2 $$2MeSH$$aThrombectomy: methods
000272873 650_2 $$2MeSH$$aMiddle Aged
000272873 650_2 $$2MeSH$$aAged, 80 and over
000272873 650_2 $$2MeSH$$aRegistries
000272873 650_2 $$2MeSH$$aEndovascular Procedures: methods
000272873 650_2 $$2MeSH$$aIschemic Stroke: surgery
000272873 650_2 $$2MeSH$$aOutcome Assessment, Health Care
000272873 650_2 $$2MeSH$$aPrognosis
000272873 650_2 $$2MeSH$$aStroke
000272873 7001_ $$0P:(DE-2719)9001511$$aWarnat-Herresthal, Stefanie$$b1$$udzne
000272873 7001_ $$0P:(DE-2719)9002246$$aSavchuk, Ivan$$b2$$udzne
000272873 7001_ $$0P:(DE-2719)2811949$$aBode, Felix$$b3$$udzne
000272873 7001_ $$aNitsch, Louisa$$b4
000272873 7001_ $$aStösser, Sebastian$$b5
000272873 7001_ $$0P:(DE-2719)9003076$$aEbrahimi, Taraneh$$b6$$udzne
000272873 7001_ $$0P:(DE-2719)9003408$$avon Danwitz, Niklas$$b7$$udzne
000272873 7001_ $$0P:(DE-2719)9003181$$aAsperger, Hannah$$b8$$udzne
000272873 7001_ $$aLayer, Julia$$b9
000272873 7001_ $$aMeissner, Julius$$b10
000272873 7001_ $$0P:(DE-2719)9002386$$aThielscher, Christian$$b11$$udzne
000272873 7001_ $$aDorn, Franziska$$b12
000272873 7001_ $$aLehnen, Nils$$b13
000272873 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b14$$udzne
000272873 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b15$$udzne
000272873 7001_ $$aWeller, Johannes M$$b16
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000272873 7001_ $$aBerrouschot, Jörg$$b19$$eContributor
000272873 7001_ $$aBoeck-Behrens, Tobias$$b20$$eContributor
000272873 7001_ $$aBohner, Georg$$b21$$eContributor
000272873 7001_ $$aBorggrefe, Jan$$b22$$eContributor
000272873 7001_ $$aBormann, Albrecht$$b23$$eContributor
000272873 7001_ $$aBraun, Michael$$b24$$eContributor
000272873 7001_ $$aDorn, Franziska$$b25$$eContributor
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000272873 7001_ $$aErnemann, Ulrike$$b27$$eContributor
000272873 7001_ $$aErnst, Marielle$$b28$$eContributor
000272873 7001_ $$aFiehler, Jens$$b29$$eContributor
000272873 7001_ $$aGröschel, Klaus$$b30$$eContributor
000272873 7001_ $$aHattingen, Jörg$$b31$$eContributor
000272873 7001_ $$aHamann, Gerhard$$b32$$eContributor
000272873 7001_ $$aHeitkamp, Christian$$b33$$eContributor
000272873 7001_ $$aHenn, Karl-Heinz$$b34$$eContributor
000272873 7001_ $$aKeil, Fee$$b35$$eContributor
000272873 7001_ $$0P:(DE-2719)9003034$$aKellert, Lars$$b36$$eContributor$$udzne
000272873 7001_ $$aLeischner, Hannes$$b37$$eContributor
000272873 7001_ $$aLudolph, Alexander$$b38$$eContributor
000272873 7001_ $$aMaier, Ilko$$b39$$eContributor
000272873 7001_ $$aNikoubashman, Omid$$b40$$eContributor
000272873 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b41$$eContributor
000272873 7001_ $$aPetersen, Martina$$b42$$eContributor
000272873 7001_ $$aPoli, Sven$$b43$$eContributor
000272873 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b44$$eContributor$$udzne
000272873 7001_ $$aReich, Arno$$b45$$eContributor
000272873 7001_ $$aRöther, Joachim$$b46$$eContributor
000272873 7001_ $$aRiedel, Christian$$b47$$eContributor
000272873 7001_ $$aSchäfer, Jan Hendrik$$b48$$eContributor
000272873 7001_ $$aSchell, Maximilian$$b49$$eContributor
000272873 7001_ $$aSchellinger, Peter$$b50$$eContributor
000272873 7001_ $$aSiebert, Eberhard$$b51$$eContributor
000272873 7001_ $$aStögbauer, Florian$$b52$$eContributor
000272873 7001_ $$aThomalla, Götz$$b53$$eContributor
000272873 7001_ $$aTiedt, Steffen$$b54$$eContributor
000272873 7001_ $$aTrumm, Christoph$$b55$$eContributor
000272873 7001_ $$aUphaus, Timo$$b56$$eContributor
000272873 7001_ $$aWunderlich, Silke$$b57$$eContributor
000272873 773__ $$0PERI:(DE-600)2740696-9$$a10.1002/acn3.52185$$gVol. 11, no. 10, p. 2696 - 2706$$n10$$p2696 - 2706$$tAnnals of Clinical and Translational Neurology$$v11$$x2328-9503$$y2024
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