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000272890 0247_ $$2doi$$a10.1093/brain/awae149
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000272890 037__ $$aDZNE-2024-01303
000272890 041__ $$aEnglish
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000272890 1001_ $$0P:(DE-2719)9000770$$aSoch, Joram$$b0$$eFirst author
000272890 245__ $$aSingle-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.
000272890 260__ $$aOxford$$bOxford Univ. Press$$c2024
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000272890 520__ $$aSingle-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive ageing. Here, we tested the utility of these scores as potential diagnostic and prognostic markers in Alzheimer's disease (AD) and risk states like mild cognitive impairment (MCI) or subjective cognitive decline (SCD). To this end, we analysed subsequent memory functional MRI data from individuals with SCD, MCI and AD dementia as well as healthy controls and first-degree relatives of AD dementia patients (AD-rel) who participated in the multi-centre DELCODE study (n = 468). Based on the individual participants' whole-brain functional MRI novelty and subsequent memory responses, we calculated the FADE and SAME scores and assessed their association with AD risk stage, neuropsychological test scores, CSF amyloid positivity and APOE genotype. Memory-based FADE and SAME scores showed a considerably larger deviation from a reference sample of young adults in the MCI and AD dementia groups compared to healthy controls, SCD and AD-rel. In addition, novelty-based scores significantly differed between the MCI and AD dementia groups. Across the entire sample, single-value scores correlated with neuropsychological test performance. The novelty-based SAME score further differed between Aβ-positive and Aβ-negative individuals in SCD and AD-rel, and between ApoE ɛ4 carriers and non-carriers in AD-rel. Hence, FADE and SAME scores are associated with both cognitive performance and individual risk factors for AD. Their potential utility as diagnostic and prognostic biomarkers warrants further exploration, particularly in individuals with SCD and healthy relatives of AD dementia patients.
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000272890 650_7 $$2Other$$aAlzheimer’s disease
000272890 650_7 $$2Other$$adementia risk
000272890 650_7 $$2Other$$afMRI scores
000272890 650_7 $$2Other$$amild cognitive impairment
000272890 650_7 $$2Other$$anovelty processing
000272890 650_7 $$2Other$$asubsequent memory
000272890 650_7 $$2NLM Chemicals$$aApolipoproteins E
000272890 650_2 $$2MeSH$$aHumans
000272890 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000272890 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000272890 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000272890 650_2 $$2MeSH$$aMale
000272890 650_2 $$2MeSH$$aFemale
000272890 650_2 $$2MeSH$$aAged
000272890 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000272890 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000272890 650_2 $$2MeSH$$aBrain: diagnostic imaging
000272890 650_2 $$2MeSH$$aMiddle Aged
000272890 650_2 $$2MeSH$$aNeuropsychological Tests
000272890 650_2 $$2MeSH$$aSeverity of Illness Index
000272890 650_2 $$2MeSH$$aAdult
000272890 650_2 $$2MeSH$$aAged, 80 and over
000272890 650_2 $$2MeSH$$aApolipoproteins E: genetics
000272890 7001_ $$00000-0001-9681-6298$$aRichter, Anni$$b1
000272890 7001_ $$0P:(DE-2719)9000615$$aKizilirmak, Jasmin M$$b2
000272890 7001_ $$0P:(DE-2719)9001467$$aSchütze, Hartmut$$b3$$udzne
000272890 7001_ $$0P:(DE-2719)2814076$$aZiegler, Gabriel$$b4$$udzne
000272890 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b5$$udzne
000272890 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b6$$udzne
000272890 7001_ $$aDechent, Peter$$b7
000272890 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b8$$udzne
000272890 7001_ $$0P:(DE-2719)2812392$$aFreiesleben, Silka Dawn$$b9$$udzne
000272890 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b10$$udzne
000272890 7001_ $$0P:(DE-2719)9001704$$aGref, Daria$$b11$$udzne
000272890 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b12$$udzne
000272890 7001_ $$aHetzer, Stefan$$b13
000272890 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I$$b14$$udzne
000272890 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b15$$udzne
000272890 7001_ $$0P:(DE-2719)9002382$$aKimmich, Okka$$b16$$udzne
000272890 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b17$$udzne
000272890 7001_ $$0P:(DE-2719)9002169$$aKuhn, Elizabeth$$b18$$udzne
000272890 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b19$$udzne
000272890 7001_ $$aLohse, Andrea$$b20
000272890 7001_ $$0P:(DE-2719)9002520$$aLüsebrink, Falk$$b21$$udzne
000272890 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b22$$udzne
000272890 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b23$$udzne
000272890 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b24$$udzne
000272890 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b25$$udzne
000272890 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b26
000272890 7001_ $$0P:(DE-2719)2810395$$aRoeske, Sandra$$b27$$udzne
000272890 7001_ $$aRostamzadeh, Ayda$$b28
000272890 7001_ $$0P:(DE-2719)2812341$$aRoy-Kluth, Nina$$b29$$udzne
000272890 7001_ $$aScheffler, Klaus$$b30
000272890 7001_ $$0P:(DE-2719)2811245$$aSchmid, Matthias$$b31$$udzne
000272890 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b32$$udzne
000272890 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b33$$udzne
000272890 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b34
000272890 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b35
000272890 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b36$$udzne
000272890 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b37$$udzne
000272890 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b38$$udzne
000272890 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b39
000272890 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn H$$b40$$eLast author
000272890 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/awae149$$gVol. 147, no. 11, p. 3789 - 3803$$n11$$p3789 - 3803$$tBrain$$v147$$x0006-8950$$y2024
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