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@ARTICLE{Soch:272890,
      author       = {Soch, Joram and Richter, Anni and Kizilirmak, Jasmin M and
                      Schütze, Hartmut and Ziegler, Gabriel and Altenstein,
                      Slawek and Brosseron, Frederic and Dechent, Peter and
                      Fliessbach, Klaus and Freiesleben, Silka Dawn and Glanz,
                      Wenzel and Gref, Daria and Heneka, Michael and Hetzer,
                      Stefan and Incesoy, Enise I and Kilimann, Ingo and Kimmich,
                      Okka and Kleineidam, Luca and Kuhn, Elizabeth and Laske,
                      Christoph and Lohse, Andrea and Lüsebrink, Falk and Munk,
                      Matthias H and Peters, Oliver and Preis, Lukas and Priller,
                      Josef and Ramirez, Alfredo and Roeske, Sandra and
                      Rostamzadeh, Ayda and Roy-Kluth, Nina and Scheffler, Klaus
                      and Schmid, Matthias and Schneider, Anja and Spottke, Annika
                      and Spruth, Eike Jakob and Teipel, Stefan and Wiltfang, Jens
                      and Jessen, Frank and Wagner, Michael and Düzel, Emrah and
                      Schott, Björn H},
      title        = {{S}ingle-value brain activity scores reflect both severity
                      and risk across the {A}lzheimer's continuum.},
      journal      = {Brain},
      volume       = {147},
      number       = {11},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2024-01303},
      pages        = {3789 - 3803},
      year         = {2024},
      abstract     = {Single-value scores reflecting the deviation from (FADE
                      score) or similarity with (SAME score) prototypical
                      novelty-related and memory-related functional MRI activation
                      patterns in young adults have been proposed as imaging
                      biomarkers of healthy neurocognitive ageing. Here, we tested
                      the utility of these scores as potential diagnostic and
                      prognostic markers in Alzheimer's disease (AD) and risk
                      states like mild cognitive impairment (MCI) or subjective
                      cognitive decline (SCD). To this end, we analysed subsequent
                      memory functional MRI data from individuals with SCD, MCI
                      and AD dementia as well as healthy controls and first-degree
                      relatives of AD dementia patients (AD-rel) who participated
                      in the multi-centre DELCODE study (n = 468). Based on the
                      individual participants' whole-brain functional MRI novelty
                      and subsequent memory responses, we calculated the FADE and
                      SAME scores and assessed their association with AD risk
                      stage, neuropsychological test scores, CSF amyloid
                      positivity and APOE genotype. Memory-based FADE and SAME
                      scores showed a considerably larger deviation from a
                      reference sample of young adults in the MCI and AD dementia
                      groups compared to healthy controls, SCD and AD-rel. In
                      addition, novelty-based scores significantly differed
                      between the MCI and AD dementia groups. Across the entire
                      sample, single-value scores correlated with
                      neuropsychological test performance. The novelty-based SAME
                      score further differed between Aβ-positive and Aβ-negative
                      individuals in SCD and AD-rel, and between ApoE ɛ4 carriers
                      and non-carriers in AD-rel. Hence, FADE and SAME scores are
                      associated with both cognitive performance and individual
                      risk factors for AD. Their potential utility as diagnostic
                      and prognostic biomarkers warrants further exploration,
                      particularly in individuals with SCD and healthy relatives
                      of AD dementia patients.},
      keywords     = {Humans / Alzheimer Disease: genetics / Alzheimer Disease:
                      psychology / Alzheimer Disease: physiopathology / Male /
                      Female / Aged / Magnetic Resonance Imaging / Cognitive
                      Dysfunction: physiopathology / Brain: diagnostic imaging /
                      Middle Aged / Neuropsychological Tests / Severity of Illness
                      Index / Adult / Aged, 80 and over / Apolipoproteins E:
                      genetics / Alzheimer’s disease (Other) / dementia risk
                      (Other) / fMRI scores (Other) / mild cognitive impairment
                      (Other) / novelty processing (Other) / subsequent memory
                      (Other) / Apolipoproteins E (NLM Chemicals)},
      cin          = {AG Fischer / Clinical Dementia Research (Göttingen) / AG
                      Wiltfang / AG Düzel / AG Endres / AG Heneka / Patient
                      Studies (Bonn) / AG Peters / AG Teipel / Clinical Research
                      (Bonn) / AG Wagner / AG Gasser / AG Spottke / AG Schmid Bonn
                      / AG Schneider / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440015 /
                      I:(DE-2719)1410006 / I:(DE-2719)5000006 / I:(DE-2719)1811005
                      / I:(DE-2719)1011303 / I:(DE-2719)1011101 /
                      I:(DE-2719)5000000 / I:(DE-2719)1510100 / I:(DE-2719)1011001
                      / I:(DE-2719)1011201 / I:(DE-2719)1210000 /
                      I:(DE-2719)1011103 / I:(DE-2719)1013028 / I:(DE-2719)1011305
                      / I:(DE-2719)1011102},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38743817},
      pmc          = {pmc:PMC11531847},
      doi          = {10.1093/brain/awae149},
      url          = {https://pub.dzne.de/record/272890},
}