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000272954 1001_ $$00000-0003-0056-1361$$aBandres-Ciga, Sara$$b0
000272954 245__ $$aNeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.
000272954 260__ $$aNew York, NY$$bWiley$$c2024
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000272954 520__ $$aCommercial genome-wide genotyping arrays have historically neglected coverage of genetic variation across populations.We aimed to create a multi-ancestry genome-wide array that would include a wide range of neuro-specific genetic content to facilitate genetic research in neurological disorders across multiple ancestral groups, fostering diversity and inclusivity in research studies.We developed the Illumina NeuroBooster Array (NBA), a custom high-throughput and cost-effective platform on a backbone of 1,914,934 variants from the Infinium Global Diversity Array and added custom content comprising 95,273 variants associated with more than 70 neurological conditions or traits, and we further tested its performance on more than 2000 patient samples. This novel platform includes approximately 10,000 tagging variants to facilitate imputation and analyses of neurodegenerative disease-related genome-wide association study loci across diverse populations.In this article, we describe NBA's potential as an efficient means for researchers to assess known and novel disease genetic associations in a multi-ancestry framework. The NBA can identify rare genetic variants and accurately impute more than 15 million common variants across populations. Apart from enabling sample prioritization for further whole-genome sequencing studies, we envisage that NBA will play a pivotal role in recruitment for interventional studies in the precision medicine space.From a broader perspective, the NBA serves as a promising means to foster collaborative research endeavors in the field of neurological disorders worldwide. Ultimately, this carefully designed tool is poised to make a substantial contribution to uncovering the genetic etiology underlying these debilitating conditions. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
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000272954 650_7 $$2Other$$aCentre for Alzheimer's and Related Dementias
000272954 650_7 $$2Other$$aGlobal Parkinson's Genetics Program
000272954 650_7 $$2Other$$aNeuroBooster array
000272954 650_7 $$2Other$$adiversity
000272954 650_7 $$2Other$$agenetic screening
000272954 650_7 $$2Other$$agenotyping
000272954 650_7 $$2Other$$aneurological diseases
000272954 650_2 $$2MeSH$$aHumans
000272954 650_2 $$2MeSH$$aGenome-Wide Association Study: methods
000272954 650_2 $$2MeSH$$aNervous System Diseases: genetics
000272954 650_2 $$2MeSH$$aGenotype
000272954 650_2 $$2MeSH$$aGenetic Variation: genetics
000272954 650_2 $$2MeSH$$aGenotyping Techniques: methods
000272954 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide: genetics
000272954 650_2 $$2MeSH$$aGenetic Predisposition to Disease: genetics
000272954 7001_ $$aFaghri, Faraz$$b1
000272954 7001_ $$aMajounie, Elisa$$b2
000272954 7001_ $$aKoretsky, Mathew J$$b3
000272954 7001_ $$00000-0003-0738-0512$$aKim, Jeffrey$$b4
000272954 7001_ $$aLevine, Kristin S$$b5
000272954 7001_ $$0P:(DE-2719)9001970$$aLeonard, Hampton$$b6
000272954 7001_ $$00000-0002-7978-1051$$aMakarious, Mary B$$b7
000272954 7001_ $$00000-0002-8982-7885$$aIwaki, Hirotaka$$b8
000272954 7001_ $$aCrea, Peter Wild$$b9
000272954 7001_ $$0P:(DE-2719)2812102$$aHernandez, Dena G$$b10
000272954 7001_ $$aArepalli, Sampath$$b11
000272954 7001_ $$aBillingsley, Kimberley$$b12
000272954 7001_ $$0P:(DE-2719)9000191$$aLohmann, Katja$$b13
000272954 7001_ $$aKlein, Christine$$b14
000272954 7001_ $$aLubbe, Steven J$$b15
000272954 7001_ $$00000-0001-6844-882X$$aJabbari, Edwin$$b16
000272954 7001_ $$aSaffie-Awad, Paula$$b17
000272954 7001_ $$00000-0002-8696-9108$$aNarendra, Derek$$b18
000272954 7001_ $$aReyes-Palomares, Armando$$b19
000272954 7001_ $$aQuinn, John P$$b20
000272954 7001_ $$0P:(DE-2719)9000366$$aSchulte, Claudia$$b21
000272954 7001_ $$00000-0002-5473-3774$$aMorris, Huw R$$b22
000272954 7001_ $$aTraynor, Bryan J$$b23
000272954 7001_ $$00000-0002-6623-0429$$aScholz, Sonja W$$b24
000272954 7001_ $$00000-0002-2866-7777$$aHoulden, Henry$$b25
000272954 7001_ $$aHardy, John$$b26
000272954 7001_ $$aDumanis, Sonya$$b27
000272954 7001_ $$aRiley, Ekemini$$b28
000272954 7001_ $$0P:(DE-2719)2810837$$aBlauwendraat, Cornelis$$b29
000272954 7001_ $$aSingleton, Andrew$$b30
000272954 7001_ $$aNalls, Mike$$b31
000272954 7001_ $$aJeff, Janina$$b32
000272954 7001_ $$aVitale, Dan$$b33
000272954 7001_ $$aAlzheimer's, Global Parkinson's Genetics Program and the Center for$$b34$$eGP2
000272954 7001_ $$aDementias, Related$$b35$$eCollaboration Author
000272954 773__ $$0PERI:(DE-600)2041249-6$$a10.1002/mds.29902$$gVol. 39, no. 11, p. 2039 - 2048$$n11$$p2039 - 2048$$tMovement disorders$$v39$$x0885-3185$$y2024
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