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@ARTICLE{BandresCiga:272954,
      author       = {Bandres-Ciga, Sara and Faghri, Faraz and Majounie, Elisa
                      and Koretsky, Mathew J and Kim, Jeffrey and Levine, Kristin
                      S and Leonard, Hampton and Makarious, Mary B and Iwaki,
                      Hirotaka and Crea, Peter Wild and Hernandez, Dena G and
                      Arepalli, Sampath and Billingsley, Kimberley and Lohmann,
                      Katja and Klein, Christine and Lubbe, Steven J and Jabbari,
                      Edwin and Saffie-Awad, Paula and Narendra, Derek and
                      Reyes-Palomares, Armando and Quinn, John P and Schulte,
                      Claudia and Morris, Huw R and Traynor, Bryan J and Scholz,
                      Sonja W and Houlden, Henry and Hardy, John and Dumanis,
                      Sonya and Riley, Ekemini and Blauwendraat, Cornelis and
                      Singleton, Andrew and Nalls, Mike and Jeff, Janina and
                      Vitale, Dan},
      collaboration = {Dementias, Related},
      othercontributors = {Alzheimer's, Global Parkinson's Genetics Program and the
                          Center for},
      title        = {{N}euro{B}ooster {A}rray: {A} {G}enome-{W}ide {G}enotyping
                      {P}latform to {S}tudy {N}eurological {D}isorders {A}cross
                      {D}iverse {P}opulations.},
      journal      = {Movement disorders},
      volume       = {39},
      number       = {11},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-01333},
      pages        = {2039 - 2048},
      year         = {2024},
      abstract     = {Commercial genome-wide genotyping arrays have historically
                      neglected coverage of genetic variation across
                      populations.We aimed to create a multi-ancestry genome-wide
                      array that would include a wide range of neuro-specific
                      genetic content to facilitate genetic research in
                      neurological disorders across multiple ancestral groups,
                      fostering diversity and inclusivity in research studies.We
                      developed the Illumina NeuroBooster Array (NBA), a custom
                      high-throughput and cost-effective platform on a backbone of
                      1,914,934 variants from the Infinium Global Diversity Array
                      and added custom content comprising 95,273 variants
                      associated with more than 70 neurological conditions or
                      traits, and we further tested its performance on more than
                      2000 patient samples. This novel platform includes
                      approximately 10,000 tagging variants to facilitate
                      imputation and analyses of neurodegenerative disease-related
                      genome-wide association study loci across diverse
                      populations.In this article, we describe NBA's potential as
                      an efficient means for researchers to assess known and novel
                      disease genetic associations in a multi-ancestry framework.
                      The NBA can identify rare genetic variants and accurately
                      impute more than 15 million common variants across
                      populations. Apart from enabling sample prioritization for
                      further whole-genome sequencing studies, we envisage that
                      NBA will play a pivotal role in recruitment for
                      interventional studies in the precision medicine space.From
                      a broader perspective, the NBA serves as a promising means
                      to foster collaborative research endeavors in the field of
                      neurological disorders worldwide. Ultimately, this carefully
                      designed tool is poised to make a substantial contribution
                      to uncovering the genetic etiology underlying these
                      debilitating conditions. © 2024 The Author(s). Movement
                      Disorders published by Wiley Periodicals LLC on behalf of
                      International Parkinson and Movement Disorder Society. This
                      article has been contributed to by U.S. Government employees
                      and their work is in the public domain in the USA.},
      keywords     = {Humans / Genome-Wide Association Study: methods / Nervous
                      System Diseases: genetics / Genotype / Genetic Variation:
                      genetics / Genotyping Techniques: methods / Polymorphism,
                      Single Nucleotide: genetics / Genetic Predisposition to
                      Disease: genetics / Centre for Alzheimer's and Related
                      Dementias (Other) / Global Parkinson's Genetics Program
                      (Other) / NeuroBooster array (Other) / diversity (Other) /
                      genetic screening (Other) / genotyping (Other) /
                      neurological diseases (Other)},
      cin          = {AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39283294},
      pmc          = {pmc:PMC11568947},
      doi          = {10.1002/mds.29902},
      url          = {https://pub.dzne.de/record/272954},
}