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000272963 1001_ $$0P:(DE-2719)2812548$$aKrüger, Dennis M$$b0$$eFirst author$$udzne
000272963 245__ $$aThe plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals.
000272963 260__ $$aHoboken, NJ$$bWiley$$c2024
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000272963 520__ $$aMicroRNAs are short non-coding RNAs that control proteostasis at the systems level and are emerging as potential prognostic and diagnostic biomarkers for Alzheimer's disease (AD).We performed small RNA sequencing on plasma samples from 847 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.We identified microRNA signatures that correlate with AD diagnoses and help predict the conversion from mild cognitive impairment (MCI) to AD.Our data demonstrate that plasma microRNA signatures can be used to not only diagnose MCI, but also, critically, predict the conversion from MCI to AD. Moreover, combined with neuropsychological testing, plasma microRNAome evaluation helps predict MCI to AD conversion. These findings are of considerable public interest because they provide a path toward reducing indiscriminate utilization of costly and invasive testing by defining the at-risk segment of the aging population.We provide the first analysis of the plasma microRNAome for the ADNI study. The levels of several microRNAs can be used as biomarkers for the prediction of conversion from MCI to AD. Adding the evaluation of plasma microRNA levels to neuropsychological testing in a clinical setting increases the accuracy of MCI to AD conversion prediction.
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000272963 650_7 $$2Other$$aAlzheimer's disease
000272963 650_7 $$2Other$$ablood biomarker
000272963 650_7 $$2Other$$acognitive decline
000272963 650_7 $$2Other$$amicroRNA
000272963 650_7 $$2Other$$amild cognitive impairment
000272963 650_7 $$2Other$$aplasma
000272963 650_7 $$2Other$$asmall non‐coding RNA
000272963 650_7 $$2NLM Chemicals$$aMicroRNAs
000272963 650_7 $$2NLM Chemicals$$aBiomarkers
000272963 650_2 $$2MeSH$$aHumans
000272963 650_2 $$2MeSH$$aAlzheimer Disease: blood
000272963 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000272963 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000272963 650_2 $$2MeSH$$aMicroRNAs: blood
000272963 650_2 $$2MeSH$$aMicroRNAs: genetics
000272963 650_2 $$2MeSH$$aCognitive Dysfunction: blood
000272963 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000272963 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000272963 650_2 $$2MeSH$$aAged
000272963 650_2 $$2MeSH$$aFemale
000272963 650_2 $$2MeSH$$aMale
000272963 650_2 $$2MeSH$$aBiomarkers: blood
000272963 650_2 $$2MeSH$$aNeuropsychological Tests: statistics & numerical data
000272963 650_2 $$2MeSH$$aDisease Progression
000272963 650_2 $$2MeSH$$aAged, 80 and over
000272963 650_2 $$2MeSH$$aNeuroimaging
000272963 7001_ $$0P:(DE-2719)2811063$$aPena Centeno, Tonatiuh$$b1$$udzne
000272963 7001_ $$aLiu, Shiwei$$b2
000272963 7001_ $$aPark, Tamina$$b3
000272963 7001_ $$0P:(DE-2719)2812832$$aKaurani, Lalit$$b4$$udzne
000272963 7001_ $$0P:(DE-2719)9001438$$aPradhan, Ranjit$$b5$$udzne
000272963 7001_ $$aHuang, Yen-Ning$$b6
000272963 7001_ $$aRisacher, Shannon L$$b7
000272963 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b8$$udzne
000272963 7001_ $$0P:(DE-2719)2810585$$aSchütz, Anna-Lena$$b9$$udzne
000272963 7001_ $$aWan, Yang$$b10
000272963 7001_ $$aShaw, Leslie M$$b11
000272963 7001_ $$aBrodsky, Alexander S$$b12
000272963 7001_ $$aDeStefano, Anita L$$b13
000272963 7001_ $$aLin, Honghuang$$b14
000272963 7001_ $$0P:(DE-HGF)0$$aSchroeder, Robert$$b15
000272963 7001_ $$aKrunic, Andre$$b16
000272963 7001_ $$0P:(DE-2719)9003058$$aHempel, Nina$$b17$$udzne
000272963 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b18$$udzne
000272963 7001_ $$aBlusztajn, Jan Krzysztof$$b19
000272963 7001_ $$aSaykin, Andrew J$$b20
000272963 7001_ $$00000-0002-1873-3064$$aDelalle, Ivana$$b21
000272963 7001_ $$aNho, Kwangsik$$b22
000272963 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b23$$eLast author$$udzne
000272963 7001_ $$aInitiative, Alzheimer's Disease Neuroimaging$$b24$$eCollaboration Author
000272963 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14157$$gVol. 20, no. 11, p. 7479 - 7494$$n11$$p7479 - 7494$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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