%0 Journal Article
%A Liu, Shiwei
%A Park, Tamina
%A Krüger, Dennis M
%A Pena Centeno, Tonatiuh
%A Burkhardt, Susanne
%A Schutz, Anna-Lena
%A Huang, Yen-Ning
%A Rosewood, Thea
%A Chaudhuri, Soumilee
%A Cho, MinYoung
%A Risacher, Shannon L
%A Wan, Yang
%A Shaw, Leslie M
%A Sananbenesi, Farahnaz
%A Brodsky, Alexander S
%A Lin, Honghuang
%A Krunic, Andre
%A Blusztajn, Jan Krzysztof
%A Saykin, Andrew J
%A Delalle, Ivana
%A Fischer, Andre
%A Nho, Kwangsik
%T Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.
%J Alzheimer's and dementia
%V 20
%N 11
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2024-01343
%P 7698 - 7714
%D 2024
%X MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis.We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers.We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enriched pathways. Additionally, 220 genes targeted by neurodegeneration-related miRNAs showed enrichment in pathways including the insulin growth factor 1 pathway. The classification performance of demographic information for A/T/N positivity was increased up to 9
%K Humans
%K Alzheimer Disease: blood
%K Alzheimer Disease: genetics
%K Biomarkers: blood
%K MicroRNAs: blood
%K MicroRNAs: genetics
%K Female
%K Male
%K Aged
%K Aged, 80 and over
%K Machine Learning
%K tau Proteins: blood
%K Amyloid beta-Peptides: blood
%K Alzheimer's disease (Other)
%K amyloid (Other)
%K biomarkers (Other)
%K classification (Other)
%K microRNAs (Other)
%K neurodegeneration (Other)
%K plasma (Other)
%K tau (Other)
%K Biomarkers (NLM Chemicals)
%K MicroRNAs (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39291737
%2 pmc:PMC11567826
%R 10.1002/alz.14230
%U https://pub.dzne.de/record/272964