TY  - JOUR
AU  - Liu, Shiwei
AU  - Park, Tamina
AU  - Krüger, Dennis M
AU  - Pena Centeno, Tonatiuh
AU  - Burkhardt, Susanne
AU  - Schutz, Anna-Lena
AU  - Huang, Yen-Ning
AU  - Rosewood, Thea
AU  - Chaudhuri, Soumilee
AU  - Cho, MinYoung
AU  - Risacher, Shannon L
AU  - Wan, Yang
AU  - Shaw, Leslie M
AU  - Sananbenesi, Farahnaz
AU  - Brodsky, Alexander S
AU  - Lin, Honghuang
AU  - Krunic, Andre
AU  - Blusztajn, Jan Krzysztof
AU  - Saykin, Andrew J
AU  - Delalle, Ivana
AU  - Fischer, Andre
AU  - Nho, Kwangsik
TI  - Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 11
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2024-01343
SP  - 7698 - 7714
PY  - 2024
AB  - MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis.We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers.We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enriched pathways. Additionally, 220 genes targeted by neurodegeneration-related miRNAs showed enrichment in pathways including the insulin growth factor 1 pathway. The classification performance of demographic information for A/T/N positivity was increased up to 9
KW  - Humans
KW  - Alzheimer Disease: blood
KW  - Alzheimer Disease: genetics
KW  - Biomarkers: blood
KW  - MicroRNAs: blood
KW  - MicroRNAs: genetics
KW  - Female
KW  - Male
KW  - Aged
KW  - Aged, 80 and over
KW  - Machine Learning
KW  - tau Proteins: blood
KW  - Amyloid beta-Peptides: blood
KW  - Alzheimer's disease (Other)
KW  - amyloid (Other)
KW  - biomarkers (Other)
KW  - classification (Other)
KW  - microRNAs (Other)
KW  - neurodegeneration (Other)
KW  - plasma (Other)
KW  - tau (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - MicroRNAs (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39291737
C2  - pmc:PMC11567826
DO  - DOI:10.1002/alz.14230
UR  - https://pub.dzne.de/record/272964
ER  -