% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Liu:272964,
      author       = {Liu, Shiwei and Park, Tamina and Krüger, Dennis M and Pena
                      Centeno, Tonatiuh and Burkhardt, Susanne and Schutz,
                      Anna-Lena and Huang, Yen-Ning and Rosewood, Thea and
                      Chaudhuri, Soumilee and Cho, MinYoung and Risacher, Shannon
                      L and Wan, Yang and Shaw, Leslie M and Sananbenesi, Farahnaz
                      and Brodsky, Alexander S and Lin, Honghuang and Krunic,
                      Andre and Blusztajn, Jan Krzysztof and Saykin, Andrew J and
                      Delalle, Ivana and Fischer, Andre and Nho, Kwangsik},
      collaboration = {Initiative, Alzheimer's Disease Neuroimaging},
      title        = {{P}lasma mi{RNA}s across the {A}lzheimer's disease
                      continuum: {R}elationship to central biomarkers.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {11},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2024-01343},
      pages        = {7698 - 7714},
      year         = {2024},
      abstract     = {MicroRNAs (miRNAs) play important roles in gene expression
                      regulation and Alzheimer's disease (AD) pathogenesis.We
                      investigated the association between baseline plasma miRNAs
                      and central AD biomarkers from the Alzheimer's Disease
                      Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and
                      neurodegeneration (A/T/N). Differentially expressed miRNAs
                      and their targets were identified, followed by pathway
                      enrichment analysis. Machine learning approaches were
                      applied to investigate the role of miRNAs as blood
                      biomarkers.We identified nine, two, and eight miRNAs
                      significantly associated with A/T/N positivity,
                      respectively. We identified 271 genes targeted by
                      amyloid-related miRNAs with estrogen signaling
                      receptor-mediated signaling among the enriched pathways.
                      Additionally, 220 genes targeted by
                      neurodegeneration-related miRNAs showed enrichment in
                      pathways including the insulin growth factor 1 pathway. The
                      classification performance of demographic information for
                      A/T/N positivity was increased up to $9\%$ with the
                      inclusion of miRNAs.Plasma miRNAs were associated with
                      central A/T/N biomarkers, highlighting their potential as
                      blood biomarkers.We performed association analysis of
                      microRNAs (miRNAs) with amyloid/tau/neurodegeneration
                      (A/T/N) biomarker positivity. We identified dysregulated
                      miRNAs for A/T/N biomarker positivity. We identified
                      Alzheimer's disease biomarker-specific/common pathways
                      related to miRNAs. miRNAs improved the classification for
                      A/T/N positivity by up to $9\%.$ Our study highlights the
                      potential of miRNAs as blood biomarkers.},
      keywords     = {Humans / Alzheimer Disease: blood / Alzheimer Disease:
                      genetics / Biomarkers: blood / MicroRNAs: blood / MicroRNAs:
                      genetics / Female / Male / Aged / Aged, 80 and over /
                      Machine Learning / tau Proteins: blood / Amyloid
                      beta-Peptides: blood / Alzheimer's disease (Other) / amyloid
                      (Other) / biomarkers (Other) / classification (Other) /
                      microRNAs (Other) / neurodegeneration (Other) / plasma
                      (Other) / tau (Other) / Biomarkers (NLM Chemicals) /
                      MicroRNAs (NLM Chemicals) / tau Proteins (NLM Chemicals) /
                      Amyloid beta-Peptides (NLM Chemicals)},
      cin          = {AG Fischer / Bioinformatics Unit (Göttingen) / AG
                      Sananbenesi},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1440016 /
                      I:(DE-2719)1410004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39291737},
      pmc          = {pmc:PMC11567826},
      doi          = {10.1002/alz.14230},
      url          = {https://pub.dzne.de/record/272964},
}