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@ARTICLE{Wu:273899,
      author       = {Wu, Jianping and Kislinger, Georg and Duschek, Jerome and
                      Durmaz, Ayşe Damla and Wefers, Benedikt and Feng, Ruoqing
                      and Nalbach, Karsten and Wurst, Wolfgang and Behrends,
                      Christian and Schifferer, Martina and Simons, Mikael},
      title        = {{N}onvesicular lipid transfer drives myelin growth in the
                      central nervous system.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2024-01378},
      pages        = {9756},
      year         = {2024},
      abstract     = {Oligodendrocytes extend numerous cellular processes that
                      wrap multiple times around axons to generate lipid-rich
                      myelin sheaths. Myelin biogenesis requires an enormously
                      productive biosynthetic machinery for generating and
                      delivering these large amounts of newly synthesized lipids.
                      Yet, a complete understanding of this process remains
                      elusive. Utilizing volume electron microscopy, we
                      demonstrate that the oligodendroglial endoplasmic reticulum
                      (ER) is enriched in developing myelin, extending into and
                      making contact with the innermost myelin layer where growth
                      occurs. We explore the possibility of transfer of lipids
                      from the ER to myelin, and find that the glycolipid transfer
                      protein (GLTP), implicated in nonvesicular lipid transport,
                      is highly enriched in the growing myelin sheath. Mice with a
                      specific knockout of Gltp in oligodendrocytes exhibit ER
                      pathology, hypomyelination and a decrease in myelin
                      glycolipid content. In summary, our results demonstrate a
                      role for nonvesicular lipid transport in CNS myelin growth,
                      revealing a cellular pathway in developmental myelination.},
      keywords     = {Animals / Myelin Sheath: metabolism / Oligodendroglia:
                      metabolism / Oligodendroglia: cytology / Mice / Central
                      Nervous System: metabolism / Central Nervous System: growth
                      $\&$ development / Mice, Knockout / Endoplasmic Reticulum:
                      metabolism / Carrier Proteins: metabolism / Carrier
                      Proteins: genetics / Lipid Metabolism / Glycolipids:
                      metabolism / Mice, Inbred C57BL / Biological Transport /
                      Carrier Proteins (NLM Chemicals) / Glycolipids (NLM
                      Chemicals) / lipid transfer protein (NLM Chemicals)},
      cin          = {AG Simons / AG Wurst / AG Misgeld},
      ddc          = {500},
      cid          = {I:(DE-2719)1110008 / I:(DE-2719)1140001 /
                      I:(DE-2719)1110000-4},
      pnm          = {351 - Brain Function (POF4-351) / 352 - Disease Mechanisms
                      (POF4-352)},
      pid          = {G:(DE-HGF)POF4-351 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39528474},
      pmc          = {pmc:PMC11554831},
      doi          = {10.1038/s41467-024-53511-y},
      url          = {https://pub.dzne.de/record/273899},
}