Home > Publications Database > Nonvesicular lipid transfer drives myelin growth in the central nervous system. > print

001     273899
005     20250120165732.0
024 7 _ |a 10.1038/s41467-024-53511-y
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041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Wu, Jianping
|0 P:(DE-2719)9000820
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245 _ _ |a Nonvesicular lipid transfer drives myelin growth in the central nervous system.
260 _ _ |a [London]
|c 2024
|b Nature Publishing Group UK
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520 _ _ |a Oligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts of newly synthesized lipids. Yet, a complete understanding of this process remains elusive. Utilizing volume electron microscopy, we demonstrate that the oligodendroglial endoplasmic reticulum (ER) is enriched in developing myelin, extending into and making contact with the innermost myelin layer where growth occurs. We explore the possibility of transfer of lipids from the ER to myelin, and find that the glycolipid transfer protein (GLTP), implicated in nonvesicular lipid transport, is highly enriched in the growing myelin sheath. Mice with a specific knockout of Gltp in oligodendrocytes exhibit ER pathology, hypomyelination and a decrease in myelin glycolipid content. In summary, our results demonstrate a role for nonvesicular lipid transport in CNS myelin growth, revealing a cellular pathway in developmental myelination.
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650 _ 7 |a Carrier Proteins
|2 NLM Chemicals
650 _ 7 |a Glycolipids
|2 NLM Chemicals
650 _ 7 |a lipid transfer protein
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Myelin Sheath: metabolism
|2 MeSH
650 _ 2 |a Oligodendroglia: metabolism
|2 MeSH
650 _ 2 |a Oligodendroglia: cytology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Central Nervous System: metabolism
|2 MeSH
650 _ 2 |a Central Nervous System: growth & development
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Endoplasmic Reticulum: metabolism
|2 MeSH
650 _ 2 |a Carrier Proteins: metabolism
|2 MeSH
650 _ 2 |a Carrier Proteins: genetics
|2 MeSH
650 _ 2 |a Lipid Metabolism
|2 MeSH
650 _ 2 |a Glycolipids: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Biological Transport
|2 MeSH
700 1 _ |a Kislinger, Georg
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700 1 _ |a Duschek, Jerome
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700 1 _ |a Durmaz, Ayşe Damla
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700 1 _ |a Wefers, Benedikt
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700 1 _ |a Feng, Ruoqing
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700 1 _ |a Nalbach, Karsten
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700 1 _ |a Wurst, Wolfgang
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700 1 _ |a Behrends, Christian
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700 1 _ |a Schifferer, Martina
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700 1 _ |a Simons, Mikael
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773 _ _ |a 10.1038/s41467-024-53511-y
|g Vol. 15, no. 1, p. 9756
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787 0 _ |a Wu, Jianping
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|t Dataset: Lipidomics of myelin from wild-type and Gltp cKO mice, v1
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