Home > Publications Database > Calibration-free whole-brain CEST imaging at 7T with parallel transmit pulse design for saturation homogeneity utilizing universal pulses (PUSHUP). > print

001     273901
005     20250127091520.0
024 7 _ |a pmc:PMC11604840
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024 7 _ |a 10.1002/mrm.30305
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024 7 _ |a pmid:39301770
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024 7 _ |a 1522-2594
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024 7 _ |a 0740-3194
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037 _ _ |a DZNE-2024-01380
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Völzke, Yannik
|0 P:(DE-2719)2811521
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245 _ _ |a Calibration-free whole-brain CEST imaging at 7T with parallel transmit pulse design for saturation homogeneity utilizing universal pulses (PUSHUP).
260 _ _ |a New York, NY [u.a.]
|c 2025
|b Wiley-Liss
336 7 _ |a article
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520 _ _ |a Chemical exchange saturation transfer (CEST) measurements at ultra-high field (UHF) suffer from strong saturation inhomogeneity. Retrospective correction of this inhomogeneity is possible to some extent, but requires a time-consuming repetition of the measurement. Here, we propose a calibration-free parallel transmit (pTx)-based saturation scheme that homogenizes the saturation over the imaging volume, which we call PUlse design for Saturation Homogeneity utilizing Universal Pulses (PUSHUP).Magnetization transfer effects depend on the saturation B 1 rms $$ {\mathrm{B}}_1^{\mathrm{rms}} $$ . PUSHUP homogenizes the saturation B 1 rms $$ {\mathrm{B}}_1^{\mathrm{rms}} $$ by using multiple saturation pulses with alternating B 1 $$ {\mathrm{B}}_1 $$ -shims. Using a database of B 1 $$ {\mathrm{B}}_1 $$ maps, universal pulses are calculated that remove the necessity of time-consuming, subject-based pulse calculation during the measurement.PUSHUP was combined with a whole-brain three-dimensional-echo planar imaging (3D-EPI) readout. Two PUSHUP saturation modules were calculated by either applying whole-brain or cerebellum masks to the database maps. The saturation homogeneity and the group mean CEST amplitudes were calculated for different B 1 $$ {\mathrm{B}}_1 $$ -correction methods and were compared to circular polarized (CP) saturation in five healthy volunteers using an eight-channel transmit coil at 7 Tesla.In contrast to CP saturation, where accurate CEST maps were impossible to obtain in the cerebellum, even with extensive B 1 $$ {\mathrm{B}}_1 $$ -correction, PUSHUP CEST maps were artifact-free throughout the whole brain. A 1-point retrospective B 1 $$ {\mathrm{B}}_1 $$ -correction, that does not need repeated measurements, sufficiently removed the effect of residual saturation inhomogeneity.The presented method allows for homogeneous whole-brain CEST imaging at 7 Tesla without the need of a repetition-based B 1 $$ {\mathrm{B}}_1 $$ -correction or online pulse calculation. With the fast 3D-EPI readout, whole-brain CEST imaging with 45 saturation offsets is possible at 1.6 mm resolution in under 4 min.
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650 _ 7 |a CEST
|2 Other
650 _ 7 |a magnetization transfer
|2 Other
650 _ 7 |a parallel transmit
|2 Other
650 _ 7 |a ultra‐high field
|2 Other
650 _ 7 |a universal pulses
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Brain: diagnostic imaging
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
650 _ 2 |a Algorithms
|2 MeSH
650 _ 2 |a Image Processing, Computer-Assisted: methods
|2 MeSH
650 _ 2 |a Phantoms, Imaging
|2 MeSH
650 _ 2 |a Calibration
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
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700 1 _ |a Akbey, Suzan
|0 P:(DE-2719)2811556
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|u dzne
700 1 _ |a Löwen, Daniel
|0 P:(DE-2719)9001317
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700 1 _ |a Pracht, Eberhard Daniel
|0 P:(DE-2719)2810559
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700 1 _ |a Stirnberg, Rüdiger
|0 P:(DE-2719)2810697
|b 4
700 1 _ |a Gras, Vincent
|0 0000-0002-4997-2738
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700 1 _ |a Boulant, Nicolas
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700 1 _ |a Zaiss, Moritz
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700 1 _ |a Stöcker, Tony
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773 _ _ |a 10.1002/mrm.30305
|g Vol. 93, no. 2, p. 630 - 642
|0 PERI:(DE-600)1493786-4
|n 2
|p 630 - 642
|t Magnetic resonance in medicine
|v 93
|y 2025
|x 1522-2594
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