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001     273915
005     20250120102327.0
024 7 _ |a 10.1152/ajpcell.00219.2024
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024 7 _ |a 0363-6143
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024 7 _ |a 1522-1563
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037 _ _ |a DZNE-2024-01389
041 _ _ |a English
082 _ _ |a 000
100 1 _ |a Schreiber, Stefanie
|0 P:(DE-2719)2812631
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245 _ _ |a Immune system activation and cognitive impairment in arterial hypertension.
260 _ _ |a Bethesda, Md.
|c 2024
|b American Physiological Society
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520 _ _ |a Chronic arterial hypertension disrupts the integrity of the cerebral microvasculature, doubling the risk of age-related dementia. Despite sufficient antihypertensive therapy in still a significant proportion of individuals blood pressure lowering alone does not preserve cognitive health. Accumulating evidence highlights the role of inflammatory mechanisms in the pathogenesis of hypertension. In this review, we introduce a temporal framework to explore how early immune system activation and interactions at neurovascular-immune interfaces pave the way to cognitive impairment. The overall paradigm suggests that prohypertensive stimuli induce mechanical stress and systemic inflammatory responses that shift peripheral and meningeal immune effector mechanisms toward a proinflammatory state. Neurovascular-immune interfaces in the brain include a dysfunctional blood-brain barrier, crossed by peripheral immune cells; the perivascular space, in which macrophages respond to cerebrospinal fluid- and blood-derived immune regulators; and the meningeal immune reservoir, particularly T cells. Immune responses at these interfaces bridge peripheral and neurovascular unit inflammation, directly contributing to impaired brain perfusion, clearance of toxic metabolites, and synaptic function. We propose that deep immunophenotyping in biofluids together with advanced neuroimaging could aid in the translational determination of sequential immune and brain endotypes specific to arterial hypertension. This could close knowledge gaps on how and when immune system activation transits into neurovascular dysfunction and cognitive impairment. In the future, targeting specific immune mechanisms could prevent and halt hypertension disease progression before clinical symptoms arise, addressing the need for new interventions against one of the leading threats to cognitive health.
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650 _ 7 |a arterial hypertension
|2 Other
650 _ 7 |a cerebral small vessel disease
|2 Other
650 _ 7 |a cognitive impairment
|2 Other
650 _ 7 |a cytokines
|2 Other
650 _ 7 |a immune system
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Hypertension: immunology
|2 MeSH
650 _ 2 |a Hypertension: physiopathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: immunology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: physiopathology
|2 MeSH
650 _ 2 |a Animals
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650 _ 2 |a Blood-Brain Barrier: immunology
|2 MeSH
650 _ 2 |a Brain: immunology
|2 MeSH
650 _ 2 |a Brain: physiopathology
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Immune System: immunology
|2 MeSH
650 _ 2 |a Immune System: physiopathology
|2 MeSH
650 _ 2 |a Immune System: metabolism
|2 MeSH
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a Inflammation: immunology
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700 1 _ |a Ulbrich, Philipp
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700 1 _ |a Morton, Lorena
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700 1 _ |a Garza, Alejandra P
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700 1 _ |a Müller, Patrick
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700 1 _ |a Neumann, Katja
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700 1 _ |a Mattern, Hendrik
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700 1 _ |a Dörner, Marc
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700 1 _ |a Bernal, Jose
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700 1 _ |a Vielhaber, Stefan
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700 1 _ |a Meuth, Sven G
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700 1 _ |a Dunay, Ildiko R
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700 1 _ |a Dityatev, Alexander
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700 1 _ |a Henneicke, Solveig
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773 _ _ |a 10.1152/ajpcell.00219.2024
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