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@ARTICLE{vonderGablentz:273926,
      author       = {von der Gablentz, Janina and Overbeeke, Nina and Timmann,
                      Dagmar and Ganos, Christos and Synofzik, Matthis and
                      Brüggemann, Norbert and Helmchen, Christoph and Sprenger,
                      Andreas},
      title        = {{P}ostural control in episodic ataxia type 2: no evidence
                      for increased vestibular excitability},
      journal      = {European journal of neurology},
      volume       = {32},
      number       = {1},
      issn         = {1351-5101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2024-01400},
      pages        = {e16520},
      year         = {2025},
      abstract     = {Patients with episodic ataxia type 2 (EA2) suffer from
                      recurrent paroxysmal episodes of vertigo and oscillopsia.
                      Pathophysiologically, altered neuronal excitability has been
                      suspected. Vestibular excitability in 22 EA2 patients and 22
                      age-matched healthy participants was compared.Galvanic
                      vestibular stimulation (GVS) was used to assess vestibular
                      excitability by vestibular motion perception thresholds and
                      mean postural sway velocity during various visual and
                      proprioceptive conditions in the two groups. Control stimuli
                      using sham and no GVS were established to identify the
                      specificity of GVS-induced postural sway.In the baseline
                      condition, EA2 patients showed larger postural instability.
                      However, motion perception thresholds and the increase in
                      mean postural sway velocity during vestibular stimulation
                      (stimulation ratio) did not differ between groups. Postural
                      sway during suprathreshold GVS increased with the vestibular
                      motion perception threshold in EA2 patients, in contrast to
                      healthy participants.The larger postural unsteadiness of EA2
                      patients probably reflects their progressive cerebellar
                      degeneration. It is not related to abnormal visual
                      (Romberg's ratio) or proprioceptive control of stance.
                      Postural unsteadiness during vestibular stimulation does not
                      indicate altered vestibular excitability in EA2 patients.
                      However, vestibular stimulation increasingly destabilized
                      postural control of EA2 patients with higher motion
                      perception thresholds when proprioceptive information was
                      diminished. This conclusion, however, is restricted to the
                      postural control of EA2 patients in the interval between the
                      vestibulo-cerebellar episodes.},
      keywords     = {Humans / Female / Male / Postural Balance: physiology /
                      Middle Aged / Adult / Ataxia: physiopathology / Vestibule,
                      Labyrinth: physiopathology / Vestibule, Labyrinth:
                      physiology / Aged / Motion Perception: physiology / Electric
                      Stimulation / Nystagmus, Pathologic},
      cin          = {AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39463030},
      pmc          = {pmc:PMC11622321},
      doi          = {10.1111/ene.16520},
      url          = {https://pub.dzne.de/record/273926},
}