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@ARTICLE{Hasenbein:273928,
      author       = {Hasenbein, Tim P and Hoelzl, Sarah and Smith, Zachary D and
                      Gerhardinger, Chiara and Gonner, Marion O C and
                      Aguilar-Pimentel, Antonio and Amarie, Oana V and Becker,
                      Lore and Calzada-Wack, Julia and Dragano, Nathalia R V and
                      da Silva-Buttkus, Patricia and Garrett, Lillian and Hölter,
                      Sabine M and Kraiger, Markus and Östereicher, Manuela A and
                      Rathkolb, Birgit and Sanz-Moreno, Adrián and Spielmann,
                      Nadine and Wurst, Wolfgang and Gailus-Durner, Valerie and
                      Fuchs, Helmut and Hrabě de Angelis, Martin and Meissner,
                      Alexander and Engelhardt, Stefan and Rinn, John L and
                      Andergassen, Daniel},
      title        = {{X}-linked deletion of {C}rossfirre, {F}irre, and {D}xz4 in
                      vivo uncovers diverse phenotypes and combinatorial effects
                      on autosomes.},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2024-01402},
      pages        = {10631},
      year         = {2024},
      abstract     = {The lncRNA Crossfirre was identified as an imprinted
                      X-linked gene, and is transcribed antisense to the
                      trans-acting lncRNA Firre. The Firre locus forms an
                      inactive-X-specific interaction with Dxz4, both loci
                      providing the platform for the largest conserved chromatin
                      structures. Here, we characterize the epigenetic profile of
                      these loci, revealing them as the most female-specific
                      accessible regions genome-wide. To address their in vivo
                      role, we perform one of the largest X-linked knockout
                      studies by deleting Crossfirre, Firre, and Dxz4 individually
                      and in combination. Despite their distinct epigenetic
                      features observed on the X chromosome, our allele-specific
                      analysis uncovers these loci as dispensable for imprinted
                      and random X chromosome inactivation. However, we provide
                      evidence that Crossfirre affects autosomal gene regulation
                      but only in combination with Firre. To shed light on the
                      functional role of these sex-specific loci, we perform an
                      extensive standardized phenotyping pipeline and uncover
                      diverse knockout and sex-specific phenotypes. Collectively,
                      our study provides the foundation for exploring the
                      intricate interplay of conserved X-linked loci in vivo.},
      keywords     = {Animals / RNA, Long Noncoding: genetics / RNA, Long
                      Noncoding: metabolism / Female / Male / Phenotype / X
                      Chromosome Inactivation: genetics / Genes, X-Linked / X
                      Chromosome: genetics / Genomic Imprinting / Mice / Mice,
                      Knockout / Epigenesis, Genetic / Alleles / Mice, Inbred
                      C57BL / RNA, Long Noncoding (NLM Chemicals)},
      cin          = {AG Wurst},
      ddc          = {500},
      cid          = {I:(DE-2719)1140001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39638999},
      pmc          = {pmc:PMC11621363},
      doi          = {10.1038/s41467-024-54673-5},
      url          = {https://pub.dzne.de/record/273928},
}