%0 Journal Article
%A Blömeke, Lara
%A Rehn, Fabian
%A Pils, Marlene
%A Kraemer-Schulien, Victoria
%A Cousin, Anneliese
%A Kutzsche, Janine
%A Bujnicki, Tuyen
%A Freiesleben, Silka D
%A Schneider, Luisa-Sophie
%A Preis, Lukas
%A Priller, Josef
%A Spruth, Eike Jakob
%A Altenstein, Slawek
%A Schneider, Anja
%A Fliessbach, Klaus
%A Wiltfang, Jens
%A Hansen, Niels
%A Rostamzadeh, Ayda
%A Düzel, Emrah
%A Glanz, Wenzel
%A Incesoy, Enise I
%A Buerger, Katharina
%A Janowitz, Daniel
%A Ewers, Michael
%A Perneczky, Robert
%A Rauchmann, Boris Stephan
%A Teipel, Stefan
%A Kilimann, Ingo
%A Laske, Christoph
%A Munk, Matthias H
%A Spottke, Annika
%A Roy, Nina
%A Heneka, Michael
%A Brosseron, Frederic
%A Wagner, Michael
%A Roeske, Sandra
%A Ramirez, Alfredo
%A Schmid, Matthias
%A Jessen, Frank
%A Bannach, Oliver
%A Peters, Oliver
%A Willbold, Dieter
%T Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects.
%J Communications medicine
%V 4
%N 1
%@ 2730-664X
%C [London]
%I Springer Nature
%M DZNE-2024-01404
%P 262
%D 2024
%X Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and selective technology because of very low Aβ oligomer concentrations and possible interference from matrix components.In this report, we developed and validated a surface-based fluorescence distribution analysis (sFIDA) assay for quantification of Aβ oligomers in plasma.The blood-based sFIDA assay delivers a sensitivity of 1.8 fM, an inter- and intra-assay variation below 20
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC11631981
%$ pmid:39658587
%R 10.1038/s43856-024-00690-w
%U https://pub.dzne.de/record/273930