TY  - JOUR
AU  - Blömeke, Lara
AU  - Rehn, Fabian
AU  - Pils, Marlene
AU  - Kraemer-Schulien, Victoria
AU  - Cousin, Anneliese
AU  - Kutzsche, Janine
AU  - Bujnicki, Tuyen
AU  - Freiesleben, Silka D
AU  - Schneider, Luisa-Sophie
AU  - Preis, Lukas
AU  - Priller, Josef
AU  - Spruth, Eike Jakob
AU  - Altenstein, Slawek
AU  - Schneider, Anja
AU  - Fliessbach, Klaus
AU  - Wiltfang, Jens
AU  - Hansen, Niels
AU  - Rostamzadeh, Ayda
AU  - Düzel, Emrah
AU  - Glanz, Wenzel
AU  - Incesoy, Enise I
AU  - Buerger, Katharina
AU  - Janowitz, Daniel
AU  - Ewers, Michael
AU  - Perneczky, Robert
AU  - Rauchmann, Boris Stephan
AU  - Teipel, Stefan
AU  - Kilimann, Ingo
AU  - Laske, Christoph
AU  - Munk, Matthias H
AU  - Spottke, Annika
AU  - Roy, Nina
AU  - Heneka, Michael
AU  - Brosseron, Frederic
AU  - Wagner, Michael
AU  - Roeske, Sandra
AU  - Ramirez, Alfredo
AU  - Schmid, Matthias
AU  - Jessen, Frank
AU  - Bannach, Oliver
AU  - Peters, Oliver
AU  - Willbold, Dieter
TI  - Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects.
JO  - Communications medicine
VL  - 4
IS  - 1
SN  - 2730-664X
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2024-01404
SP  - 262
PY  - 2024
AB  - Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer's Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive and selective technology because of very low Aβ oligomer concentrations and possible interference from matrix components.In this report, we developed and validated a surface-based fluorescence distribution analysis (sFIDA) assay for quantification of Aβ oligomers in plasma.The blood-based sFIDA assay delivers a sensitivity of 1.8 fM, an inter- and intra-assay variation below 20
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11631981
C6  - pmid:39658587
DO  - DOI:10.1038/s43856-024-00690-w
UR  - https://pub.dzne.de/record/273930
ER  -