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@ARTICLE{Blmeke:273930,
      author       = {Blömeke, Lara and Rehn, Fabian and Pils, Marlene and
                      Kraemer-Schulien, Victoria and Cousin, Anneliese and
                      Kutzsche, Janine and Bujnicki, Tuyen and Freiesleben, Silka
                      D and Schneider, Luisa-Sophie and Preis, Lukas and Priller,
                      Josef and Spruth, Eike Jakob and Altenstein, Slawek and
                      Schneider, Anja and Fliessbach, Klaus and Wiltfang, Jens and
                      Hansen, Niels and Rostamzadeh, Ayda and Düzel, Emrah and
                      Glanz, Wenzel and Incesoy, Enise I and Buerger, Katharina
                      and Janowitz, Daniel and Ewers, Michael and Perneczky,
                      Robert and Rauchmann, Boris Stephan and Teipel, Stefan and
                      Kilimann, Ingo and Laske, Christoph and Munk, Matthias H and
                      Spottke, Annika and Roy, Nina and Heneka, Michael and
                      Brosseron, Frederic and Wagner, Michael and Roeske, Sandra
                      and Ramirez, Alfredo and Schmid, Matthias and Jessen, Frank
                      and Bannach, Oliver and Peters, Oliver and Willbold, Dieter},
      title        = {{B}lood-based quantification of {A}β oligomers indicates
                      impaired clearance from brain in {A}po{E} ε4 positive
                      subjects.},
      journal      = {Communications medicine},
      volume       = {4},
      number       = {1},
      issn         = {2730-664X},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2024-01404},
      pages        = {262},
      year         = {2024},
      abstract     = {Quantification of Amyloid beta (Aβ) oligomers in plasma
                      enables early diagnosis of Alzheimer's Disease (AD) and
                      improves our understanding of underlying pathologies.
                      However, quantification necessitates an extremely sensitive
                      and selective technology because of very low Aβ oligomer
                      concentrations and possible interference from matrix
                      components.In this report, we developed and validated a
                      surface-based fluorescence distribution analysis (sFIDA)
                      assay for quantification of Aβ oligomers in plasma.The
                      blood-based sFIDA assay delivers a sensitivity of 1.8 fM, an
                      inter- and intra-assay variation below $20\%$ for oligomer
                      calibration standards and no interference with matrix
                      components. Quantification of Aβ oligomers in 359 plasma
                      samples from the DELCODE cohort reveals lower oligomer
                      concentrations in subjective cognitive decline and AD
                      patients than healthy Control participants.Correlation
                      analysis between CSF and plasma oligomer concentrations
                      indicates an impaired clearance of Aβ oligomers that is
                      dependent on the ApoE ε4 status.},
      cin          = {AG Peters / AG Dirnagl / AG Endres / AG Düzel / AG Priller
                      / AG Schneider / Patient Studies (Bonn) / AG Wiltfang /
                      Clinical Research (Munich) / AG Dichgans / AG Teipel / AG
                      Gasser / AG Spottke / Clinical Research Platform (CRP) / AG
                      Wagner / AG Jessen / AG Schmid Bonn / AG Heneka},
      cid          = {I:(DE-2719)5000000 / I:(DE-2719)1810002 /
                      I:(DE-2719)1811005 / I:(DE-2719)5000006 / I:(DE-2719)5000007
                      / I:(DE-2719)1011305 / I:(DE-2719)1011101 /
                      I:(DE-2719)1410006 / I:(DE-2719)1111015 / I:(DE-2719)5000022
                      / I:(DE-2719)1510100 / I:(DE-2719)1210000 /
                      I:(DE-2719)1011103 / I:(DE-2719)1011401 / I:(DE-2719)1011201
                      / I:(DE-2719)1011102 / I:(DE-2719)1013028 /
                      I:(DE-2719)1011303},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11631981},
      pubmed       = {pmid:39658587},
      doi          = {10.1038/s43856-024-00690-w},
      url          = {https://pub.dzne.de/record/273930},
}