%0 Journal Article
%A Müller, Patrick
%A Reinsberger, Claus
%A Schreiber, Stefanie
%A Braun-Dullaeus, Rüdiger
%T Physical Activity and Neurodegenerative Diseases: Potential Role in Prevention and Therapy
%J Deutsche Zeitschrift für Sportmedizin
%V 75
%N 7
%@ 0344-5925
%C Augsburg
%I Dynamic Media Sales Verlag
%M DZNE-2024-01408
%P 257 - 260
%D 2024
%X Physical activity and exercise are low-cost interventions in primary and secondary prevention of several noncommunicable diseas(e.g. cardiovascular diseases, chronic kidney disease, neurodegenerative and neurovascular disease). › In the context of demographic change, the relative and absolute numbers of patients with neurological, especially neurodegenerativdisease, will increase. Based on missing causal therapies and high costs, non-pharmacological (e.g. physical activity) approaches for healthaging are gaining attention. › Epidemiological, observational, and randomized controlled studies have shown that physical activity can enhance brain plasticity and im-prove cognitive vitality over lifespan. However, the underlying neurobiological mechanisms are still largely unknown. Physical activity can influencdifferent risk factors for neurovascular and neurodegenerative diseases (e.g. arterial hypertension, obesity). Moreover, physical activity can induccellular and molecular changes (level 1) followed by structural and functionals brain changes (level 2) and/or behavioural adaptations (level 3). › In this clinical review we summarize the role of physical activity in the prevention and therapy of neurological disease. 
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.5960/dzsm.2024.615
%U https://pub.dzne.de/record/273934