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@ARTICLE{Mller:273934,
      author       = {Müller, Patrick and Reinsberger, Claus and Schreiber,
                      Stefanie and Braun-Dullaeus, Rüdiger},
      title        = {{P}hysical {A}ctivity and {N}eurodegenerative {D}iseases:
                      {P}otential {R}ole in {P}revention and {T}herapy},
      journal      = {Deutsche Zeitschrift für Sportmedizin},
      volume       = {75},
      number       = {7},
      issn         = {0344-5925},
      address      = {Augsburg},
      publisher    = {Dynamic Media Sales Verlag},
      reportid     = {DZNE-2024-01408},
      pages        = {257 - 260},
      year         = {2024},
      abstract     = {Physical activity and exercise are low-cost interventions
                      in primary and secondary prevention of several
                      noncommunicable diseas(e.g. cardiovascular diseases, chronic
                      kidney disease, neurodegenerative and neurovascular
                      disease). › In the context of demographic change, the
                      relative and absolute numbers of patients with neurological,
                      especially neurodegenerativdisease, will increase. Based on
                      missing causal therapies and high costs, non-pharmacological
                      (e.g. physical activity) approaches for healthaging are
                      gaining attention. › Epidemiological, observational, and
                      randomized controlled studies have shown that physical
                      activity can enhance brain plasticity and im-prove cognitive
                      vitality over lifespan. However, the underlying
                      neurobiological mechanisms are still largely unknown.
                      Physical activity can influencdifferent risk factors for
                      neurovascular and neurodegenerative diseases (e.g. arterial
                      hypertension, obesity). Moreover, physical activity can
                      induccellular and molecular changes (level 1) followed by
                      structural and functionals brain changes (level 2) and/or
                      behavioural adaptations (level 3). › In this clinical
                      review we summarize the role of physical activity in the
                      prevention and therapy of neurological disease.},
      subtyp        = {Review Article},
      cin          = {AG Müller / AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)1310003 / I:(DE-2719)1310010},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.5960/dzsm.2024.615},
      url          = {https://pub.dzne.de/record/273934},
}