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024 7 _ |a 10.5960/dzsm.2024.615
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024 7 _ |a 2627-2458
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037 _ _ |a DZNE-2024-01408
082 _ _ |a 610
100 1 _ |a Müller, Patrick
|0 P:(DE-2719)2811487
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|e First author
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245 _ _ |a Physical Activity and Neurodegenerative Diseases: Potential Role in Prevention and Therapy
260 _ _ |a Augsburg
|c 2024
|b Dynamic Media Sales Verlag
336 7 _ |a article
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520 _ _ |a Physical activity and exercise are low-cost interventions in primary and secondary prevention of several noncommunicable diseas(e.g. cardiovascular diseases, chronic kidney disease, neurodegenerative and neurovascular disease). › In the context of demographic change, the relative and absolute numbers of patients with neurological, especially neurodegenerativdisease, will increase. Based on missing causal therapies and high costs, non-pharmacological (e.g. physical activity) approaches for healthaging are gaining attention. › Epidemiological, observational, and randomized controlled studies have shown that physical activity can enhance brain plasticity and im-prove cognitive vitality over lifespan. However, the underlying neurobiological mechanisms are still largely unknown. Physical activity can influencdifferent risk factors for neurovascular and neurodegenerative diseases (e.g. arterial hypertension, obesity). Moreover, physical activity can induccellular and molecular changes (level 1) followed by structural and functionals brain changes (level 2) and/or behavioural adaptations (level 3). › In this clinical review we summarize the role of physical activity in the prevention and therapy of neurological disease.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
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700 1 _ |a Reinsberger, Claus
|b 1
700 1 _ |a Schreiber, Stefanie
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700 1 _ |a Braun-Dullaeus, Rüdiger
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773 _ _ |a 10.5960/dzsm.2024.615
|g Vol. 75, no. 7, p. 257 - 260
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|p 257 - 260
|t Deutsche Zeitschrift für Sportmedizin
|v 75
|y 2024
|x 0344-5925
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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914 1 _ |y 2024
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