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000273937 041__ $$aEnglish
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000273937 1001_ $$0P:(DE-2719)9001013$$aDeng, Yushuang$$b0$$eFirst author$$udzne
000273937 245__ $$aAnalysis of the senescence-associated cell surfaceome reveals potential senotherapeutic targets.
000273937 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2024
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000273937 520__ $$aThe accumulation of senescent cells is thought to play a crucial role in aging-associated physiological decline and the pathogenesis of various age-related pathologies. Targeting senescence-associated cell surface molecules through immunotherapy emerges as a promising avenue for the selective removal of these cells. Despite its potential, a thorough characterization of senescence-specific surface proteins remains to be achieved. Our study addresses this gap by conducting an extensive analysis of the cell surface proteome, or 'surfaceome', in senescent cells, spanning various senescence induction regimes and encompassing both murine and human cell types. Utilizing quantitative mass spectrometry, we investigated enriched cell surface proteins across eight distinct models of senescence. Our results uncover significant changes in surfaceome expression profiles during senescence, highlighting extensive modifications in cell mechanics and extracellular matrix remodeling. Our research also reveals substantive heterogeneity of senescence, predominantly influenced by cell type and senescence inducer. A key discovery of our study is the identification of four unique cell surface proteins with extracellular epitopes. These proteins are expressed in senescent cells, absent or present at low levels in their proliferating counterparts, and notably upregulated in tissues from aged mice and an Alzheimer's disease mouse model. These proteins stand out as promising candidates for senotherapeutic targeting, offering potential pathways for the detection and strategic targeting of senescent cell populations in aging and age-related diseases.
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000273937 650_7 $$2Other$$aaging
000273937 650_7 $$2Other$$acell surface proteins
000273937 650_7 $$2Other$$acellular senescence
000273937 650_7 $$2Other$$amass spectrometry
000273937 650_7 $$2Other$$asenotherapeutics
000273937 650_7 $$2NLM Chemicals$$aSenotherapeutics
000273937 650_7 $$2NLM Chemicals$$aMembrane Proteins
000273937 650_2 $$2MeSH$$aCellular Senescence: drug effects
000273937 650_2 $$2MeSH$$aAnimals
000273937 650_2 $$2MeSH$$aHumans
000273937 650_2 $$2MeSH$$aMice
000273937 650_2 $$2MeSH$$aSenotherapeutics: pharmacology
000273937 650_2 $$2MeSH$$aAging: metabolism
000273937 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000273937 7001_ $$0P:(DE-2719)9002571$$aLiu, Ting$$b1$$udzne
000273937 7001_ $$0P:(DE-2719)2812562$$aScifo, Enzo$$b2$$udzne
000273937 7001_ $$aLi, Tao$$b3
000273937 7001_ $$0P:(DE-2719)2810906$$aXie, Kan$$b4$$udzne
000273937 7001_ $$0P:(DE-2719)2812256$$aTaschler, Bernd$$b5$$udzne
000273937 7001_ $$0P:(DE-2719)9002881$$aMorsy, Sarah$$b6$$udzne
000273937 7001_ $$0P:(DE-2719)2812495$$aSchaaf, Kristina$$b7$$udzne
000273937 7001_ $$aEhninger, Armin$$b8
000273937 7001_ $$0P:(DE-2719)2158358$$aBano, Daniele$$b9$$udzne
000273937 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b10$$eLast author
000273937 773__ $$0PERI:(DE-600)2099130-7$$a10.1111/acel.14312$$gVol. 23, no. 12, p. e14312$$n12$$pe14312$$tAging cell$$v23$$x1474-9718$$y2024
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