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@ARTICLE{Deng:273937,
      author       = {Deng, Yushuang and Liu, Ting and Scifo, Enzo and Li, Tao
                      and Xie, Kan and Taschler, Bernd and Morsy, Sarah and
                      Schaaf, Kristina and Ehninger, Armin and Bano, Daniele and
                      Ehninger, Dan},
      title        = {{A}nalysis of the senescence-associated cell surfaceome
                      reveals potential senotherapeutic targets.},
      journal      = {Aging cell},
      volume       = {23},
      number       = {12},
      issn         = {1474-9718},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2024-01411},
      pages        = {e14312},
      year         = {2024},
      abstract     = {The accumulation of senescent cells is thought to play a
                      crucial role in aging-associated physiological decline and
                      the pathogenesis of various age-related pathologies.
                      Targeting senescence-associated cell surface molecules
                      through immunotherapy emerges as a promising avenue for the
                      selective removal of these cells. Despite its potential, a
                      thorough characterization of senescence-specific surface
                      proteins remains to be achieved. Our study addresses this
                      gap by conducting an extensive analysis of the cell surface
                      proteome, or 'surfaceome', in senescent cells, spanning
                      various senescence induction regimes and encompassing both
                      murine and human cell types. Utilizing quantitative mass
                      spectrometry, we investigated enriched cell surface proteins
                      across eight distinct models of senescence. Our results
                      uncover significant changes in surfaceome expression
                      profiles during senescence, highlighting extensive
                      modifications in cell mechanics and extracellular matrix
                      remodeling. Our research also reveals substantive
                      heterogeneity of senescence, predominantly influenced by
                      cell type and senescence inducer. A key discovery of our
                      study is the identification of four unique cell surface
                      proteins with extracellular epitopes. These proteins are
                      expressed in senescent cells, absent or present at low
                      levels in their proliferating counterparts, and notably
                      upregulated in tissues from aged mice and an Alzheimer's
                      disease mouse model. These proteins stand out as promising
                      candidates for senotherapeutic targeting, offering potential
                      pathways for the detection and strategic targeting of
                      senescent cell populations in aging and age-related
                      diseases.},
      keywords     = {Cellular Senescence: drug effects / Animals / Humans / Mice
                      / Senotherapeutics: pharmacology / Aging: metabolism /
                      Membrane Proteins: metabolism / aging (Other) / cell surface
                      proteins (Other) / cellular senescence (Other) / mass
                      spectrometry (Other) / senotherapeutics (Other) /
                      Senotherapeutics (NLM Chemicals) / Membrane Proteins (NLM
                      Chemicals)},
      cin          = {AG Ehninger / AG Bano},
      ddc          = {610},
      cid          = {I:(DE-2719)1013005 / I:(DE-2719)1013003},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39228130},
      pmc          = {pmc:PMC11634743},
      doi          = {10.1111/acel.14312},
      url          = {https://pub.dzne.de/record/273937},
}