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000273940 1001_ $$0P:(DE-2719)9001084$$aKlose, Veronika$$b0$$eFirst author
000273940 245__ $$aBlood-CSF barrier integrity in amyotrophic lateral sclerosis.
000273940 260__ $$aOxford$$bOxford Univ. Press$$c2024
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000273940 520__ $$aThe integrity of the blood-CSF barrier plays a major role in inflammation, but also in shielding the CNS from external and systemic-potentially toxic-factors. Here we report results of measurements of the albumin quotient-which is thought to mirror the integrity of the blood-CSF barrier-in 1059 patients with amyotrophic lateral sclerosis. The results were compared with groups of patients suffering from Alzheimer's disease, facial palsy and tension headache. The albumin quotient, an accepted measure of the blood-CSF barrier integrity, was not significantly different from control populations. In addition, we found that the albumin quotient correlated with survival of the patients; this effect was mainly driven by male patients and influenced by age, body mass index and diabetes mellitus. We conclude that the blood-CSF barrier is intact in this large cohort of patients with amyotrophic lateral sclerosis and that the albumin quotient correlates with survival. Whether this is important for the pathogenesis of the disease, requires mechanistic studies.
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000273940 650_7 $$2Other$$aalbumin quotient
000273940 650_7 $$2Other$$aamyotrophic lateral sclerosis
000273940 650_7 $$2Other$$ablood-CSF barrier
000273940 650_7 $$2Other$$acerebrospinal fluid
000273940 650_7 $$2Other$$asurvival
000273940 650_7 $$2NLM Chemicals$$aAlbumins
000273940 650_2 $$2MeSH$$aHumans
000273940 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis
000273940 650_2 $$2MeSH$$aMale
000273940 650_2 $$2MeSH$$aFemale
000273940 650_2 $$2MeSH$$aMiddle Aged
000273940 650_2 $$2MeSH$$aAged
000273940 650_2 $$2MeSH$$aBlood-Brain Barrier: metabolism
000273940 650_2 $$2MeSH$$aAdult
000273940 650_2 $$2MeSH$$aAlbumins: metabolism
000273940 650_2 $$2MeSH$$aAged, 80 and over
000273940 650_2 $$2MeSH$$aCohort Studies
000273940 7001_ $$0P:(DE-2719)9001441$$aJesse, Sarah$$b1$$udzne
000273940 7001_ $$00000-0002-9272-529X$$aLewerenz, Jan$$b2
000273940 7001_ $$0P:(DE-2719)9001967$$aKassubek, Jan$$b3
000273940 7001_ $$0P:(DE-2719)9001951$$aDorst, Johannes$$b4$$udzne
000273940 7001_ $$aRosenbohm, Angela$$b5
000273940 7001_ $$aNagel, Gabriele$$b6
000273940 7001_ $$aWernecke, Deborah$$b7
000273940 7001_ $$0P:(DE-2719)2812851$$aRoselli, Francesco$$b8
000273940 7001_ $$0P:(DE-2719)9002007$$aTumani, Hayrettin$$b9$$udzne
000273940 7001_ $$0P:(DE-2719)2812633$$aLudolph, Albert C$$b10$$eLast author$$udzne
000273940 773__ $$0PERI:(DE-600)1474117-9$$a10.1093/brain/awae144$$gVol. 147, no. 12, p. 4254 - 4264$$n12$$p4254 - 4264$$tBrain$$v147$$x0006-8950$$y2024
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