TY  - JOUR
AU  - Klose, Veronika
AU  - Jesse, Sarah
AU  - Lewerenz, Jan
AU  - Kassubek, Jan
AU  - Dorst, Johannes
AU  - Rosenbohm, Angela
AU  - Nagel, Gabriele
AU  - Wernecke, Deborah
AU  - Roselli, Francesco
AU  - Tumani, Hayrettin
AU  - Ludolph, Albert C
TI  - Blood-CSF barrier integrity in amyotrophic lateral sclerosis.
JO  - Brain
VL  - 147
IS  - 12
SN  - 0006-8950
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2024-01414
SP  - 4254 - 4264
PY  - 2024
AB  - The integrity of the blood-CSF barrier plays a major role in inflammation, but also in shielding the CNS from external and systemic-potentially toxic-factors. Here we report results of measurements of the albumin quotient-which is thought to mirror the integrity of the blood-CSF barrier-in 1059 patients with amyotrophic lateral sclerosis. The results were compared with groups of patients suffering from Alzheimer's disease, facial palsy and tension headache. The albumin quotient, an accepted measure of the blood-CSF barrier integrity, was not significantly different from control populations. In addition, we found that the albumin quotient correlated with survival of the patients; this effect was mainly driven by male patients and influenced by age, body mass index and diabetes mellitus. We conclude that the blood-CSF barrier is intact in this large cohort of patients with amyotrophic lateral sclerosis and that the albumin quotient correlates with survival. Whether this is important for the pathogenesis of the disease, requires mechanistic studies.
KW  - Humans
KW  - Amyotrophic Lateral Sclerosis
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Aged
KW  - Blood-Brain Barrier: metabolism
KW  - Adult
KW  - Albumins: metabolism
KW  - Aged, 80 and over
KW  - Cohort Studies
KW  - albumin quotient (Other)
KW  - amyotrophic lateral sclerosis (Other)
KW  - blood-CSF barrier (Other)
KW  - cerebrospinal fluid (Other)
KW  - survival (Other)
KW  - Albumins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:38743595
DO  - DOI:10.1093/brain/awae144
UR  - https://pub.dzne.de/record/273940
ER  -