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@ARTICLE{Klose:273940,
      author       = {Klose, Veronika and Jesse, Sarah and Lewerenz, Jan and
                      Kassubek, Jan and Dorst, Johannes and Rosenbohm, Angela and
                      Nagel, Gabriele and Wernecke, Deborah and Roselli, Francesco
                      and Tumani, Hayrettin and Ludolph, Albert C},
      title        = {{B}lood-{CSF} barrier integrity in amyotrophic lateral
                      sclerosis.},
      journal      = {Brain},
      volume       = {147},
      number       = {12},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2024-01414},
      pages        = {4254 - 4264},
      year         = {2024},
      abstract     = {The integrity of the blood-CSF barrier plays a major role
                      in inflammation, but also in shielding the CNS from external
                      and systemic-potentially toxic-factors. Here we report
                      results of measurements of the albumin quotient-which is
                      thought to mirror the integrity of the blood-CSF barrier-in
                      1059 patients with amyotrophic lateral sclerosis. The
                      results were compared with groups of patients suffering from
                      Alzheimer's disease, facial palsy and tension headache. The
                      albumin quotient, an accepted measure of the blood-CSF
                      barrier integrity, was not significantly different from
                      control populations. In addition, we found that the albumin
                      quotient correlated with survival of the patients; this
                      effect was mainly driven by male patients and influenced by
                      age, body mass index and diabetes mellitus. We conclude that
                      the blood-CSF barrier is intact in this large cohort of
                      patients with amyotrophic lateral sclerosis and that the
                      albumin quotient correlates with survival. Whether this is
                      important for the pathogenesis of the disease, requires
                      mechanistic studies.},
      keywords     = {Humans / Amyotrophic Lateral Sclerosis / Male / Female /
                      Middle Aged / Aged / Blood-Brain Barrier: metabolism / Adult
                      / Albumins: metabolism / Aged, 80 and over / Cohort Studies
                      / albumin quotient (Other) / amyotrophic lateral sclerosis
                      (Other) / blood-CSF barrier (Other) / cerebrospinal fluid
                      (Other) / survival (Other) / Albumins (NLM Chemicals)},
      cin          = {Clinical Study Center (Ulm) / AG Zhan / AG Roselli},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077 / I:(DE-2719)1910005 /
                      I:(DE-2719)1910001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354 /
                      G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38743595},
      doi          = {10.1093/brain/awae144},
      url          = {https://pub.dzne.de/record/273940},
}