%0 Journal Article
%A Alaeddin, Nersi
%A Koch, Alexandra
%A Etteldorf, Rika
%A Stingl, Julia C
%A Breteler, Monique M B
%A de Vries, Folgerdiena M
%T The impact of proton pump inhibitors on brain health based on cross-sectional findings from the Rhineland Study.
%J Scientific reports
%V 14
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2024-01429
%P 30486
%D 2024
%X Reports linking proton pump inhibitors (PPIs) with cognition and dementia show conflicting results, with limited evidence on underlying biological mechanisms. However, existing studies did not investigate brain microstructure, which could provide valuable insights into early structural changes indicative of cognitive decline. Analyses were based on cross-sectional baseline data from the Rhineland Study (n = 7,465; mean age 55.3 ± 13.7 years, range 30-95 years, 56.5
%K Humans
%K Proton Pump Inhibitors: adverse effects
%K Proton Pump Inhibitors: pharmacology
%K Female
%K Middle Aged
%K Male
%K Aged
%K Cross-Sectional Studies
%K Adult
%K Brain: drug effects
%K Brain: diagnostic imaging
%K Aged, 80 and over
%K Cognition: drug effects
%K White Matter: drug effects
%K White Matter: diagnostic imaging
%K Diffusion Tensor Imaging
%K Cognitive Dysfunction: chemically induced
%K Proton Pump Inhibitors (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC11649697
%$ pmid:39681582
%R 10.1038/s41598-024-81011-y
%U https://pub.dzne.de/record/273994