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000273994 1001_ $$0P:(DE-2719)2814259$$aAlaeddin, Nersi$$b0$$eFirst author$$udzne
000273994 245__ $$aThe impact of proton pump inhibitors on brain health based on cross-sectional findings from the Rhineland Study.
000273994 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2024
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000273994 520__ $$aReports linking proton pump inhibitors (PPIs) with cognition and dementia show conflicting results, with limited evidence on underlying biological mechanisms. However, existing studies did not investigate brain microstructure, which could provide valuable insights into early structural changes indicative of cognitive decline. Analyses were based on cross-sectional baseline data from the Rhineland Study (n = 7,465; mean age 55.3 ± 13.7 years, range 30-95 years, 56.5% women). Using multivariate linear regression, we investigated associations between PPI use and cognition and brain macro- and microstructural measures (fractional anisotropy (FA) and mean diffusivity (MD) as measures of white matter integrity). Analyses were stratified by short-term (< 3 years) and long-term (≥ 3 years) PPI use, with additional age stratification (< 65 years; ≥65 years) for cognitive outcomes. PPI users, especially younger individuals, showed poorer global cognition and working memory. Notably, younger long-term users had worse total memory. PPI use was not associated with brain volume or FA, but both short-term and long-term users showed higher MD in cognitive-related brain regions. Our findings indicate that prolonged PPI use, particularly in younger long-term users, is associated with poorer cognitive performance. Moreover, PPI users showed higher MD, indicating potential white matter integrity disruptions. Further research is needed to ascertain causality and underlying mechanisms behind PPI-related cognitive decline.
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000273994 650_7 $$2NLM Chemicals$$aProton Pump Inhibitors
000273994 650_2 $$2MeSH$$aHumans
000273994 650_2 $$2MeSH$$aProton Pump Inhibitors: adverse effects
000273994 650_2 $$2MeSH$$aProton Pump Inhibitors: pharmacology
000273994 650_2 $$2MeSH$$aFemale
000273994 650_2 $$2MeSH$$aMiddle Aged
000273994 650_2 $$2MeSH$$aMale
000273994 650_2 $$2MeSH$$aAged
000273994 650_2 $$2MeSH$$aCross-Sectional Studies
000273994 650_2 $$2MeSH$$aAdult
000273994 650_2 $$2MeSH$$aBrain: drug effects
000273994 650_2 $$2MeSH$$aBrain: diagnostic imaging
000273994 650_2 $$2MeSH$$aAged, 80 and over
000273994 650_2 $$2MeSH$$aCognition: drug effects
000273994 650_2 $$2MeSH$$aWhite Matter: drug effects
000273994 650_2 $$2MeSH$$aWhite Matter: diagnostic imaging
000273994 650_2 $$2MeSH$$aDiffusion Tensor Imaging
000273994 650_2 $$2MeSH$$aCognitive Dysfunction: chemically induced
000273994 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000273994 7001_ $$0P:(DE-2719)2810822$$aKoch, Alexandra$$b1$$udzne
000273994 7001_ $$0P:(DE-2719)9002576$$aEtteldorf, Rika$$b2$$udzne
000273994 7001_ $$aStingl, Julia C$$b3
000273994 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique M B$$b4$$udzne
000273994 7001_ $$0P:(DE-2719)2811717$$ade Vries, Folgerdiena M$$b5$$eLast author$$udzne
000273994 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-024-81011-y$$gVol. 14, no. 1, p. 30486$$n1$$p30486$$tScientific reports$$v14$$x2045-2322$$y2024
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