TY  - JOUR
AU  - Alaeddin, Nersi
AU  - Koch, Alexandra
AU  - Etteldorf, Rika
AU  - Stingl, Julia C
AU  - Breteler, Monique M B
AU  - de Vries, Folgerdiena M
TI  - The impact of proton pump inhibitors on brain health based on cross-sectional findings from the Rhineland Study.
JO  - Scientific reports
VL  - 14
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DZNE-2024-01429
SP  - 30486
PY  - 2024
AB  - Reports linking proton pump inhibitors (PPIs) with cognition and dementia show conflicting results, with limited evidence on underlying biological mechanisms. However, existing studies did not investigate brain microstructure, which could provide valuable insights into early structural changes indicative of cognitive decline. Analyses were based on cross-sectional baseline data from the Rhineland Study (n = 7,465; mean age 55.3 ± 13.7 years, range 30-95 years, 56.5
KW  - Humans
KW  - Proton Pump Inhibitors: adverse effects
KW  - Proton Pump Inhibitors: pharmacology
KW  - Female
KW  - Middle Aged
KW  - Male
KW  - Aged
KW  - Cross-Sectional Studies
KW  - Adult
KW  - Brain: drug effects
KW  - Brain: diagnostic imaging
KW  - Aged, 80 and over
KW  - Cognition: drug effects
KW  - White Matter: drug effects
KW  - White Matter: diagnostic imaging
KW  - Diffusion Tensor Imaging
KW  - Cognitive Dysfunction: chemically induced
KW  - Proton Pump Inhibitors (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11649697
C6  - pmid:39681582
DO  - DOI:10.1038/s41598-024-81011-y
UR  - https://pub.dzne.de/record/273994
ER  -