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000274005 1001_ $$0P:(DE-2719)9002598$$aBauer, Tobias$$b0$$eFirst author
000274005 245__ $$aProof of concept: Portable ultra-low-field magnetic resonance imaging for the diagnosis of epileptogenic brain pathologies.
000274005 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2024
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000274005 520__ $$aHigh-field magnetic resonance imaging (MRI) is a standard in the diagnosis of epilepsy. However, high costs and technical barriers have limited adoption in low- and middle-income countries. Even in high-income nations, many individuals with epilepsy face delays in undergoing MRI. Recent advancements in ultra-low-field (ULF) MRI technology, particularly the development of portable scanners, offer a promising solution to the limited accessibility of MRI. In this study, we present and evaluate the imaging capability of ULF MRI in detecting structural abnormalities typically associated with epilepsy and compare it to high-field MRI at 3 T.Data collection was conducted within 3 consecutive weeks at the University Hospital Bonn. Inclusion criteria were a minimum age of 18 years, diagnosed epilepsy, and clinical high-field MRI with abnormalities. We used a .064 T Swoop portable MR Imaging System. Both high-field MRI and ULF MRI scans were evaluated independently by two experienced neuroradiologists as part of their clinical routine, comparing pathology detection and diagnosis completeness.Twenty-three individuals with epilepsy were recruited. One subject presented with a dual pathology. Across the entire cohort, in 17 of 24 (71%) pathologies, an anomaly colocalizing with the actual lesion was observed on ULF MRI. For 11 of 24 (46%) pathologies, the full diagnosis could be made based on ULF MRI. Tumors and posttraumatic lesions could be diagnosed best on ULF MRI, whereas cortical dysplasia and other focal pathologies were the least well diagnosed.This single-center series of individuals with epilepsy demonstrates the feasibility and utility of ULF MRI for the field of epileptology. Its integration into epilepsy care offers transformative potential, particularly in resource-limited settings. Further research is needed to position ULF MRI within imaging modalities in the diagnosis of epilepsy.
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000274005 650_7 $$2Other$$aEpilepsy
000274005 650_7 $$2Other$$aGlobal Epileptology
000274005 650_7 $$2Other$$aNeuroimaging
000274005 650_7 $$2Other$$aSustainability
000274005 650_7 $$2Other$$alimited ressources
000274005 650_2 $$2MeSH$$aHumans
000274005 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000274005 650_2 $$2MeSH$$aEpilepsy: diagnostic imaging
000274005 650_2 $$2MeSH$$aMale
000274005 650_2 $$2MeSH$$aFemale
000274005 650_2 $$2MeSH$$aAdult
000274005 650_2 $$2MeSH$$aYoung Adult
000274005 650_2 $$2MeSH$$aMiddle Aged
000274005 650_2 $$2MeSH$$aAdolescent
000274005 650_2 $$2MeSH$$aProof of Concept Study
000274005 650_2 $$2MeSH$$aBrain: diagnostic imaging
000274005 650_2 $$2MeSH$$aBrain: pathology
000274005 7001_ $$aOlbrich, Simon$$b1
000274005 7001_ $$aGroteklaes, Anne$$b2
000274005 7001_ $$aLehnen, Nils Christian$$b3
000274005 7001_ $$aZidan, Mousa$$b4
000274005 7001_ $$aLange, Annalena$$b5
000274005 7001_ $$aBisten, Justus$$b6
000274005 7001_ $$00000-0002-3300-6877$$aWalger, Lennart$$b7
000274005 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b8$$udzne
000274005 7001_ $$aBruchhausen, Walter$$b9
000274005 7001_ $$aVollmuth, Philipp$$b10
000274005 7001_ $$aHerrlinger, Ulrich$$b11
000274005 7001_ $$0P:(DE-2719)9001861$$aRadbruch, Alexander$$b12$$udzne
000274005 7001_ $$aSurges, Rainer$$b13
000274005 7001_ $$0P:(DE-2719)9000732$$aSabir, Hemmen$$b14$$udzne
000274005 7001_ $$00000-0002-6180-7671$$aRüber, Theodor$$b15$$eLast author
000274005 773__ $$0PERI:(DE-600)2002194-X$$a10.1111/epi.18171$$gVol. 65, no. 12, p. 3607 - 3618$$n12$$p3607 - 3618$$tEpilepsia$$v65$$x0013-9580$$y2024
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