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@ARTICLE{Bauer:274005,
      author       = {Bauer, Tobias and Olbrich, Simon and Groteklaes, Anne and
                      Lehnen, Nils Christian and Zidan, Mousa and Lange, Annalena
                      and Bisten, Justus and Walger, Lennart and Faber, Jennifer
                      and Bruchhausen, Walter and Vollmuth, Philipp and
                      Herrlinger, Ulrich and Radbruch, Alexander and Surges,
                      Rainer and Sabir, Hemmen and Rüber, Theodor},
      title        = {{P}roof of concept: {P}ortable ultra-low-field magnetic
                      resonance imaging for the diagnosis of epileptogenic brain
                      pathologies.},
      journal      = {Epilepsia},
      volume       = {65},
      number       = {12},
      issn         = {0013-9580},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2024-01433},
      pages        = {3607 - 3618},
      year         = {2024},
      abstract     = {High-field magnetic resonance imaging (MRI) is a standard
                      in the diagnosis of epilepsy. However, high costs and
                      technical barriers have limited adoption in low- and
                      middle-income countries. Even in high-income nations, many
                      individuals with epilepsy face delays in undergoing MRI.
                      Recent advancements in ultra-low-field (ULF) MRI technology,
                      particularly the development of portable scanners, offer a
                      promising solution to the limited accessibility of MRI. In
                      this study, we present and evaluate the imaging capability
                      of ULF MRI in detecting structural abnormalities typically
                      associated with epilepsy and compare it to high-field MRI at
                      3 T.Data collection was conducted within 3 consecutive weeks
                      at the University Hospital Bonn. Inclusion criteria were a
                      minimum age of 18 years, diagnosed epilepsy, and clinical
                      high-field MRI with abnormalities. We used a .064 T Swoop
                      portable MR Imaging System. Both high-field MRI and ULF MRI
                      scans were evaluated independently by two experienced
                      neuroradiologists as part of their clinical routine,
                      comparing pathology detection and diagnosis
                      completeness.Twenty-three individuals with epilepsy were
                      recruited. One subject presented with a dual pathology.
                      Across the entire cohort, in 17 of 24 $(71\%)$ pathologies,
                      an anomaly colocalizing with the actual lesion was observed
                      on ULF MRI. For 11 of 24 $(46\%)$ pathologies, the full
                      diagnosis could be made based on ULF MRI. Tumors and
                      posttraumatic lesions could be diagnosed best on ULF MRI,
                      whereas cortical dysplasia and other focal pathologies were
                      the least well diagnosed.This single-center series of
                      individuals with epilepsy demonstrates the feasibility and
                      utility of ULF MRI for the field of epileptology. Its
                      integration into epilepsy care offers transformative
                      potential, particularly in resource-limited settings.
                      Further research is needed to position ULF MRI within
                      imaging modalities in the diagnosis of epilepsy.},
      keywords     = {Humans / Magnetic Resonance Imaging: methods / Epilepsy:
                      diagnostic imaging / Male / Female / Adult / Young Adult /
                      Middle Aged / Adolescent / Proof of Concept Study / Brain:
                      diagnostic imaging / Brain: pathology / Epilepsy (Other) /
                      Global Epileptology (Other) / Neuroimaging (Other) /
                      Sustainability (Other) / limited ressources (Other)},
      cin          = {AG Stöcker / Clinical Research (Bonn) / AG Radbruch / AG
                      Sabir},
      ddc          = {610},
      cid          = {I:(DE-2719)1013026 / I:(DE-2719)1011001 /
                      I:(DE-2719)5000075 / I:(DE-2719)5000032},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 353
                      - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-353 /
                      G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11647431},
      pubmed       = {pmid:39470733},
      doi          = {10.1111/epi.18171},
      url          = {https://pub.dzne.de/record/274005},
}