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000274014 1001_ $$0P:(DE-2719)9002359$$aHass, Simon$$b0$$eFirst author
000274014 245__ $$aEnvironmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults
000274014 260__ $$aLausanne$$bFrontiers Research Foundation$$c2024
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000274014 520__ $$a In humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study assessed whether EE during early life (13-30 years) and midlife (30-65 years) is associated with better preserved memory-related brain activity patterns in older age.In total, 372 cognitively unimpaired older adults (aged ≥60 years old) of the DZNE-Longitudinal Study on Cognitive Impairment and Dementia (DELCODE; DRKS00007966) were investigated. EE was operationalized using items of the Lifetime of Experiences Questionnaire (LEQ), which measures the self-reported participation in a variety of leisure activities in early life and midlife. The preservation of memory-related functional brain activity was assessed using single-value scores, which relate older adults' brain activity patterns in the temporo-parieto-occipital memory network to those of young adults during visual memory encoding (FADE and SAME scores).EE during early life and midlife was significantly associated with higher SAME scores during novelty processing (n = 372, β = 0.13, p = 0.011). Thus, older participants with higher EE showed greater similarity of functional brain activity patterns during novelty processing with young adults. This positive association was observed most strongly in participants with subjective cognitive decline (SCD, n = 199, β = 0.20, p = 0.006).More frequent participation in a variety of leisure activities in early life and midlife is associated with more successful aging of functional brain activity patterns in the memory network of older adults, including participants at increased risk for dementia. Longitudinal studies are needed to clarify whether higher EE during life could help preserve memory network function in later life.
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000274014 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000274014 7001_ $$0P:(DE-2719)9001827$$aLiebscher, Maxie$$b1
000274014 7001_ $$aRichter, Anni$$b2
000274014 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b3
000274014 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b4
000274014 7001_ $$0P:(DE-2719)9003152$$aSodenkamp, Sebastian$$b5
000274014 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b6
000274014 7001_ $$0P:(DE-2719)9003016$$aHellmann-Regen, Julian$$b7
000274014 7001_ $$0P:(DE-2719)9002917$$aErsözlü, Ersin$$b8
000274014 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b9
000274014 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b10
000274014 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b11
000274014 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b12
000274014 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b13
000274014 7001_ $$0P:(DE-2719)9001467$$aSchütze, Hartmut$$b14
000274014 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b15
000274014 7001_ $$0P:(DE-2719)9002699$$aEsser, Anna$$b16
000274014 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b17
000274014 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b18
000274014 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b19
000274014 7001_ $$aRostamzadeh, Ayda$$b20
000274014 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b21
000274014 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I.$$b22
000274014 7001_ $$0P:(DE-2719)9002520$$aLüsebrink, Falk$$b23
000274014 7001_ $$aDechent, Peter$$b24
000274014 7001_ $$aHetzer, Stefan$$b25
000274014 7001_ $$aScheffler, Klaus$$b26
000274014 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b27
000274014 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b28
000274014 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b29
000274014 7001_ $$aGlöckner, Franka$$b30
000274014 7001_ $$0P:(DE-2719)2814326$$aSchott, Björn Hendrik$$b31
000274014 7001_ $$0P:(DE-2719)2814122$$aWirth, Miranka$$b32$$eLast author
000274014 7001_ $$0P:(DE-2719)9002456$$aKlimecki, Olga$$b33$$eLast author
000274014 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2024.1451850$$gVol. 16, p. 1451850$$p1451850$$tFrontiers in aging neuroscience$$v16$$x1663-4365$$y2024
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