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@ARTICLE{Hass:274014,
      author       = {Hass, Simon and Liebscher, Maxie and Richter, Anni and
                      Fliessbach, Klaus and Laske, Christoph and Sodenkamp,
                      Sebastian and Peters, Oliver and Hellmann-Regen, Julian and
                      Ersözlü, Ersin and Priller, Josef and Spruth, Eike Jakob
                      and Altenstein, Slawek and Röske, Sandra and Schneider,
                      Anja and Schütze, Hartmut and Spottke, Annika and Esser,
                      Anna and Teipel, Stefan and Kilimann, Ingo and Wiltfang,
                      Jens and Rostamzadeh, Ayda and Glanz, Wenzel and Incesoy,
                      Enise I. and Lüsebrink, Falk and Dechent, Peter and Hetzer,
                      Stefan and Scheffler, Klaus and Wagner, Michael and Jessen,
                      Frank and Düzel, Emrah and Glöckner, Franka and Schott,
                      Björn Hendrik and Wirth, Miranka and Klimecki, Olga},
      title        = {{E}nvironmental enrichment is associated with favorable
                      memory-related functional brain activity patterns in older
                      adults},
      journal      = {Frontiers in aging neuroscience},
      volume       = {16},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00001},
      pages        = {1451850},
      year         = {2024},
      abstract     = {In humans, environmental enrichment (EE), as measured by
                      the engagement in a variety of leisure activities, has been
                      associated with larger hippocampal structure and better
                      memory function. The present cross-sectional study assessed
                      whether EE during early life (13-30 years) and midlife
                      (30-65 years) is associated with better preserved
                      memory-related brain activity patterns in older age.In
                      total, 372 cognitively unimpaired older adults (aged ≥60
                      years old) of the DZNE-Longitudinal Study on Cognitive
                      Impairment and Dementia (DELCODE; DRKS00007966) were
                      investigated. EE was operationalized using items of the
                      Lifetime of Experiences Questionnaire (LEQ), which measures
                      the self-reported participation in a variety of leisure
                      activities in early life and midlife. The preservation of
                      memory-related functional brain activity was assessed using
                      single-value scores, which relate older adults' brain
                      activity patterns in the temporo-parieto-occipital memory
                      network to those of young adults during visual memory
                      encoding (FADE and SAME scores).EE during early life and
                      midlife was significantly associated with higher SAME scores
                      during novelty processing (n = 372, β = 0.13, p = 0.011).
                      Thus, older participants with higher EE showed greater
                      similarity of functional brain activity patterns during
                      novelty processing with young adults. This positive
                      association was observed most strongly in participants with
                      subjective cognitive decline (SCD, n = 199, β = 0.20, p =
                      0.006).More frequent participation in a variety of leisure
                      activities in early life and midlife is associated with more
                      successful aging of functional brain activity patterns in
                      the memory network of older adults, including participants
                      at increased risk for dementia. Longitudinal studies are
                      needed to clarify whether higher EE during life could help
                      preserve memory network function in later life.},
      cin          = {AG Wirth / Patient Studies (Bonn) / AG Fischer / AG Gasser
                      / ICRU / AG Peters / AG Endres / AG Dirnagl / AG Priller /
                      AG Wagner / AG Schneider / AG Düzel / AG Spottke / AG
                      Teipel / AG Wiltfang / AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1011101 /
                      I:(DE-2719)1410002 / I:(DE-2719)1210000 / I:(DE-2719)1240005
                      / I:(DE-2719)5000000 / I:(DE-2719)1811005 /
                      I:(DE-2719)1810002 / I:(DE-2719)5000007 / I:(DE-2719)1011201
                      / I:(DE-2719)1011305 / I:(DE-2719)5000006 /
                      I:(DE-2719)1011103 / I:(DE-2719)1510100 / I:(DE-2719)1410006
                      / I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11704887},
      pubmed       = {pmid:39777046},
      doi          = {10.3389/fnagi.2024.1451850},
      url          = {https://pub.dzne.de/record/274014},
}