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000274021 1001_ $$0P:(DE-2719)9001766$$aXu, Peng$$b0$$eFirst author
000274021 245__ $$aHypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studies.
000274021 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2024
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000274021 520__ $$aEmerging findings indicate that the hypothalamus, the body's principal homeostatic centre, plays a crucial role in modulating cognition, but comprehensive population-based studies are lacking.We used cross-sectional data from the Rhineland Study (N = 5812, 55.2 ± 13.6 years, 58% women) and the UK Biobank Imaging Study (UKB) (N = 45,076, 64.2 ± 7.7 years, 53% women), two large-scale population-based cohort studies. Volumes of hypothalamic structures were obtained from 3T structural magnetic resonance images through an automatic parcellation procedure (FastSurfer-HypVINN). The standardised cognitive domain scores were derived from extensive neuropsychological test batteries. We employed multivariable linear regression to assess associations of hypothalamic volumes with age, sex and cognitive performance.In older individuals, volumes of total, anterior and posterior hypothalamus, and mammillary bodies were smaller, while those of medial hypothalamus and tuberal region were larger. Larger medial hypothalamus volume was related to higher cortisol levels in older individuals, providing functional validation. Volumes of all hypothalamic structures were larger in men compared to women. In both sexes, larger volumes of total, anterior and posterior hypothalamus, and mammillary bodies were associated with better domain-specific cognitive performance, whereas larger volumes of medial hypothalamus and tuberal region were associated with worse domain-specific cognitive performance.We found strong age and sex effects on hypothalamic structures, as well as robust associations between these structures and domain-specific cognitive functions. Overall, these findings thus implicate specific hypothalamic subregions as potential therapeutic targets against age-associated cognitive decline.Institutional funds, Federal Ministry of Education and Research of Germany, Alzheimer's Association.
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000274021 650_7 $$2Other$$aAge-associated cognitive decline
000274021 650_7 $$2Other$$aBrain imaging
000274021 650_7 $$2Other$$aCognitive function
000274021 650_7 $$2Other$$aCortisol
000274021 650_7 $$2Other$$aHypothalamus
000274021 650_7 $$2Other$$aSexual dimorphism
000274021 650_2 $$2MeSH$$aHumans
000274021 650_2 $$2MeSH$$aFemale
000274021 650_2 $$2MeSH$$aMale
000274021 650_2 $$2MeSH$$aMiddle Aged
000274021 650_2 $$2MeSH$$aCognition: physiology
000274021 650_2 $$2MeSH$$aHypothalamus
000274021 650_2 $$2MeSH$$aAged
000274021 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000274021 650_2 $$2MeSH$$aAdult
000274021 650_2 $$2MeSH$$aCohort Studies
000274021 650_2 $$2MeSH$$aOrgan Size
000274021 650_2 $$2MeSH$$aLongevity
000274021 650_2 $$2MeSH$$aSex Factors
000274021 650_2 $$2MeSH$$aAge Factors
000274021 650_2 $$2MeSH$$aNeuropsychological Tests
000274021 650_2 $$2MeSH$$aCross-Sectional Studies
000274021 650_2 $$2MeSH$$aAging: physiology
000274021 693__ $$0EXP:(DE-2719)Rhineland Study-20190321$$5EXP:(DE-2719)Rhineland Study-20190321$$eRhineland Study / Bonn$$x0
000274021 7001_ $$0P:(DE-2719)2812449$$aEstrada Leon, Edgar Santiago$$b1
000274021 7001_ $$0P:(DE-2719)9002576$$aEtteldorf, Rika$$b2
000274021 7001_ $$0P:(DE-2719)2813521$$aLiu, Dan$$b3
000274021 7001_ $$0P:(DE-2719)2811036$$aShahid, Mohammad$$b4
000274021 7001_ $$0P:(DE-2719)9000827$$aZeng, Weiyi$$b5
000274021 7001_ $$0P:(DE-2719)9002655$$aFrüh, Deborah$$b6
000274021 7001_ $$0P:(DE-2719)2812134$$aReuter, Martin$$b7
000274021 7001_ $$0P:(DE-2719)2810403$$aBreteler, Monique$$b8
000274021 7001_ $$0P:(DE-2719)2812578$$aAziz, N. Ahmad$$b9$$eLast author
000274021 773__ $$0PERI:(DE-600)2799017-5$$a10.1016/j.ebiom.2024.105513$$gVol. 111, p. 105513 -$$p105513$$tEBioMedicine$$v111$$x2352-3964$$y2024
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