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000274023 0247_ $$2ISSN$$a0340-5354
000274023 0247_ $$2ISSN$$a1432-1459
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000274023 1001_ $$00000-0002-2854-4179$$aFanciulli, Alessandra$$b0
000274023 245__ $$aDiagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline 'Parkinson's disease' of the German Society of Neurology.
000274023 260__ $$aHeidelberg$$bSpringer$$c2025
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000274023 520__ $$aNon-motor symptoms frequently develop throughout the disease course of Parkinson's disease (PD), and pose affected individuals at risk of complications, more rapid disease progression and poorer quality of life. Addressing such symptom burden, the 2023 revised 'Parkinson's disease' guideline of the German Society of Neurology aimed at providing evidence-based recommendations for managing PD non-motor symptoms, including autonomic failure, pain and sleep disturbances.Key PICO (Patient, Intervention, Comparison, Outcome) questions were formulated by the steering committee and refined by the assigned authors. Recommendations were drafted based on relevant studies, systematic reviews, meta-analyses and high-quality guidelines identified by the literature search. They were subsequently reviewed, revised, and voted by the Guideline Group in online consensus conferences. Consensus was achieved in case of > 75% agreement among the group members. The consensus was considered strong, if agreement was > 95%.The guideline entails: (i) 10 PICOs and 23 recommendations on the diagnosis and treatment of urogenital, cardiovascular and gastrointestinal autonomic failure; (ii) four PICOs and four recommendations on the possible types of pain in PD individuals, their diagnosis and treatment; (iii) 11 PICOs and 11 recommendations on the screening, diagnosis and treatment of sleep disturbances and excessive daytime sleepiness in PD individuals, as well as on their prognostic implications. Thirty-one out of 38 recommendations achieved a strong consensus.The current German PD guideline provides a practice-oriented and etiology-driven stepwise approach to the diagnosis and treatment of autonomic failure, pain and sleep disturbances in PD individuals.
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000274023 650_7 $$2Other$$aConstipation
000274023 650_7 $$2Other$$aDaytime sleepiness
000274023 650_7 $$2Other$$aErectile dysfunction
000274023 650_7 $$2Other$$aNocturia
000274023 650_7 $$2Other$$aOrthostatic hypotension
000274023 650_7 $$2Other$$aPain
000274023 650_7 $$2Other$$aParkinson’s disease
000274023 650_7 $$2Other$$aREM-sleep behavior disorder
000274023 650_7 $$2Other$$aSleep
000274023 650_7 $$2Other$$aSupine hypertension
000274023 650_7 $$2Other$$aUrinary incontinence
000274023 650_2 $$2MeSH$$aHumans
000274023 650_2 $$2MeSH$$aParkinson Disease: complications
000274023 650_2 $$2MeSH$$aParkinson Disease: diagnosis
000274023 650_2 $$2MeSH$$aParkinson Disease: therapy
000274023 650_2 $$2MeSH$$aSleep Wake Disorders: etiology
000274023 650_2 $$2MeSH$$aSleep Wake Disorders: therapy
000274023 650_2 $$2MeSH$$aSleep Wake Disorders: diagnosis
000274023 650_2 $$2MeSH$$aGermany
000274023 650_2 $$2MeSH$$aPain: etiology
000274023 650_2 $$2MeSH$$aPain: diagnosis
000274023 650_2 $$2MeSH$$aAutonomic Nervous System Diseases: etiology
000274023 650_2 $$2MeSH$$aAutonomic Nervous System Diseases: diagnosis
000274023 650_2 $$2MeSH$$aAutonomic Nervous System Diseases: therapy
000274023 650_2 $$2MeSH$$aNeurology: standards
000274023 650_2 $$2MeSH$$aSocieties, Medical: standards
000274023 7001_ $$aSixel-Döring, Friederike$$b1
000274023 7001_ $$aBuhmann, Carsten$$b2
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000274023 7001_ $$0P:(DE-2719)2814194$$aHermann, Wiebke$$b4$$udzne
000274023 7001_ $$aWinkler, Christian$$b5
000274023 7001_ $$aWoitalla, Dirk$$b6
000274023 7001_ $$aJost, Wolfgang H$$b7
000274023 7001_ $$aGroup, German Parkinson’s Guideline$$b8$$eCollaboration Author
000274023 7001_ $$aTrenkwalder, Claudia$$b9
000274023 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter$$b10$$eLast author$$udzne
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