TY - JOUR AU - Fanciulli, Alessandra AU - Sixel-Döring, Friederike AU - Buhmann, Carsten AU - Krismer, Florian AU - Hermann, Wiebke AU - Winkler, Christian AU - Woitalla, Dirk AU - Jost, Wolfgang H AU - Trenkwalder, Claudia AU - Höglinger, Günter TI - Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline 'Parkinson's disease' of the German Society of Neurology. JO - Journal of neurology VL - 272 IS - 1 SN - 0367-004X CY - Heidelberg PB - Springer M1 - DZNE-2025-00004 SP - 90 PY - 2025 AB - Non-motor symptoms frequently develop throughout the disease course of Parkinson's disease (PD), and pose affected individuals at risk of complications, more rapid disease progression and poorer quality of life. Addressing such symptom burden, the 2023 revised 'Parkinson's disease' guideline of the German Society of Neurology aimed at providing evidence-based recommendations for managing PD non-motor symptoms, including autonomic failure, pain and sleep disturbances.Key PICO (Patient, Intervention, Comparison, Outcome) questions were formulated by the steering committee and refined by the assigned authors. Recommendations were drafted based on relevant studies, systematic reviews, meta-analyses and high-quality guidelines identified by the literature search. They were subsequently reviewed, revised, and voted by the Guideline Group in online consensus conferences. Consensus was achieved in case of > 75 KW - Humans KW - Parkinson Disease: complications KW - Parkinson Disease: diagnosis KW - Parkinson Disease: therapy KW - Sleep Wake Disorders: etiology KW - Sleep Wake Disorders: therapy KW - Sleep Wake Disorders: diagnosis KW - Germany KW - Pain: etiology KW - Pain: diagnosis KW - Autonomic Nervous System Diseases: etiology KW - Autonomic Nervous System Diseases: diagnosis KW - Autonomic Nervous System Diseases: therapy KW - Neurology: standards KW - Societies, Medical: standards KW - Constipation (Other) KW - Daytime sleepiness (Other) KW - Erectile dysfunction (Other) KW - Nocturia (Other) KW - Orthostatic hypotension (Other) KW - Pain (Other) KW - Parkinson’s disease (Other) KW - REM-sleep behavior disorder (Other) KW - Sleep (Other) KW - Supine hypertension (Other) KW - Urinary incontinence (Other) LB - PUB:(DE-HGF)16 C6 - pmid:39751950 C2 - pmc:PMC11698777 DO - DOI:10.1007/s00415-024-12730-5 UR - https://pub.dzne.de/record/274023 ER -