% IMPORTANT: The following is UTF-8 encoded. This means that in the presence % of non-ASCII characters, it will not work with BibTeX 0.99 or older. % Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or % “biber”. @ARTICLE{Fanciulli:274023, author = {Fanciulli, Alessandra and Sixel-Döring, Friederike and Buhmann, Carsten and Krismer, Florian and Hermann, Wiebke and Winkler, Christian and Woitalla, Dirk and Jost, Wolfgang H and Trenkwalder, Claudia and Höglinger, Günter}, collaboration = {Group, German Parkinson’s Guideline}, othercontributors = {Bähr, Mathias and Becktepe, Jos and Berg, Daniela and Brockmann, Kathrin and Ceballos-Baumann, Andrés and Claßen, Joseph and Deuschl, Cornelius and Deuschl, Günther and Dodel, Richard and Ebersbach, Georg and Beelitz-Heilstätten and Eggers, Carsten and Eimeren, Thilo and Fimm, Bruno and Folkerts, Ann-Kristin and Gausepohl, Madeleine and Segeberg, Bad and Hasan, Alkomiet and Hilker-Roggendorf, Rüdiger and Höllerhage, Matthias and Hopfner, Franziska and Jost, Wolfgang and Kalbe, Elke and Kassubek, Jan and Klebe, Stephan and Klein, Christine and Klietz, Martin and Köglsperger, Thomas and Kühn, Andrea and Krack, Paul and Krismer, Florian and Kuhlenbäumer, Gregor and Levin, Johannes and Liepelt-Scarfone, Inga and Lingor, Paul and Loewenbrück, Kai and Löhle, Matthias and Lorenzl, Stefan and Maaß, Sylvia and Maetzler, Walter and Menzel, Regina and Meyer, Philipp T and Mollenhauer, Brit and Neumann, Manuela and Odin, Per and Outeiro, Tiago and Pötter-Nerger, Monika and Reese, René and Reetz, Kathrin and Rieß, Olaf and Ruf, Viktoria and Schneider, Anja and Schrader, Christoph and Schnitzler, Alfons and Seppi, Klaus and Storch, Alexander and Tönges, Lars and Eimeren, Thilo and Walter, Uwe and Wächter, Tobias and Warnecke, Tobias and Wegner, Florian and Witt, Karsten and Woitalla, Dirk and Zeuner, Kirsten}, title = {{D}iagnosis and treatment of autonomic failure, pain and sleep disturbances in {P}arkinson's disease: guideline '{P}arkinson's disease' of the {G}erman {S}ociety of {N}eurology.}, journal = {Journal of neurology}, volume = {272}, number = {1}, issn = {0367-004X}, address = {Heidelberg}, publisher = {Springer}, reportid = {DZNE-2025-00004}, pages = {90}, year = {2025}, abstract = {Non-motor symptoms frequently develop throughout the disease course of Parkinson's disease (PD), and pose affected individuals at risk of complications, more rapid disease progression and poorer quality of life. Addressing such symptom burden, the 2023 revised 'Parkinson's disease' guideline of the German Society of Neurology aimed at providing evidence-based recommendations for managing PD non-motor symptoms, including autonomic failure, pain and sleep disturbances.Key PICO (Patient, Intervention, Comparison, Outcome) questions were formulated by the steering committee and refined by the assigned authors. Recommendations were drafted based on relevant studies, systematic reviews, meta-analyses and high-quality guidelines identified by the literature search. They were subsequently reviewed, revised, and voted by the Guideline Group in online consensus conferences. Consensus was achieved in case of > $75\%$ agreement among the group members. The consensus was considered strong, if agreement was > $95\%.The$ guideline entails: (i) 10 PICOs and 23 recommendations on the diagnosis and treatment of urogenital, cardiovascular and gastrointestinal autonomic failure; (ii) four PICOs and four recommendations on the possible types of pain in PD individuals, their diagnosis and treatment; (iii) 11 PICOs and 11 recommendations on the screening, diagnosis and treatment of sleep disturbances and excessive daytime sleepiness in PD individuals, as well as on their prognostic implications. Thirty-one out of 38 recommendations achieved a strong consensus.The current German PD guideline provides a practice-oriented and etiology-driven stepwise approach to the diagnosis and treatment of autonomic failure, pain and sleep disturbances in PD individuals.}, subtyp = {Review Article}, keywords = {Humans / Parkinson Disease: complications / Parkinson Disease: diagnosis / Parkinson Disease: therapy / Sleep Wake Disorders: etiology / Sleep Wake Disorders: therapy / Sleep Wake Disorders: diagnosis / Germany / Pain: etiology / Pain: diagnosis / Autonomic Nervous System Diseases: etiology / Autonomic Nervous System Diseases: diagnosis / Autonomic Nervous System Diseases: therapy / Neurology: standards / Societies, Medical: standards / Constipation (Other) / Daytime sleepiness (Other) / Erectile dysfunction (Other) / Nocturia (Other) / Orthostatic hypotension (Other) / Pain (Other) / Parkinson’s disease (Other) / REM-sleep behavior disorder (Other) / Sleep (Other) / Supine hypertension (Other) / Urinary incontinence (Other)}, cin = {Clinical Research (Munich) / AG Storch}, ddc = {610}, cid = {I:(DE-2719)1111015 / I:(DE-2719)5000014}, pnm = {353 - Clinical and Health Care Research (POF4-353)}, pid = {G:(DE-HGF)POF4-353}, typ = {PUB:(DE-HGF)16}, pubmed = {pmid:39751950}, pmc = {pmc:PMC11698777}, doi = {10.1007/s00415-024-12730-5}, url = {https://pub.dzne.de/record/274023}, }