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@ARTICLE{Fanciulli:274023,
author = {Fanciulli, Alessandra and Sixel-Döring, Friederike and
Buhmann, Carsten and Krismer, Florian and Hermann, Wiebke
and Winkler, Christian and Woitalla, Dirk and Jost, Wolfgang
H and Trenkwalder, Claudia and Höglinger, Günter},
collaboration = {Group, German Parkinson’s Guideline},
othercontributors = {Bähr, Mathias and Becktepe, Jos and Berg, Daniela and
Brockmann, Kathrin and Ceballos-Baumann, Andrés and
Claßen, Joseph and Deuschl, Cornelius and Deuschl, Günther
and Dodel, Richard and Ebersbach, Georg and
Beelitz-Heilstätten and Eggers, Carsten and Eimeren, Thilo
and Fimm, Bruno and Folkerts, Ann-Kristin and Gausepohl,
Madeleine and Segeberg, Bad and Hasan, Alkomiet and
Hilker-Roggendorf, Rüdiger and Höllerhage, Matthias and
Hopfner, Franziska and Jost, Wolfgang and Kalbe, Elke and
Kassubek, Jan and Klebe, Stephan and Klein, Christine and
Klietz, Martin and Köglsperger, Thomas and Kühn, Andrea
and Krack, Paul and Krismer, Florian and Kuhlenbäumer,
Gregor and Levin, Johannes and Liepelt-Scarfone, Inga and
Lingor, Paul and Loewenbrück, Kai and Löhle, Matthias and
Lorenzl, Stefan and Maaß, Sylvia and Maetzler, Walter and
Menzel, Regina and Meyer, Philipp T and Mollenhauer, Brit
and Neumann, Manuela and Odin, Per and Outeiro, Tiago and
Pötter-Nerger, Monika and Reese, René and Reetz, Kathrin
and Rieß, Olaf and Ruf, Viktoria and Schneider, Anja and
Schrader, Christoph and Schnitzler, Alfons and Seppi, Klaus
and Storch, Alexander and Tönges, Lars and Eimeren, Thilo
and Walter, Uwe and Wächter, Tobias and Warnecke, Tobias
and Wegner, Florian and Witt, Karsten and Woitalla, Dirk and
Zeuner, Kirsten},
title = {{D}iagnosis and treatment of autonomic failure, pain and
sleep disturbances in {P}arkinson's disease: guideline
'{P}arkinson's disease' of the {G}erman {S}ociety of
{N}eurology.},
journal = {Journal of neurology},
volume = {272},
number = {1},
issn = {0367-004X},
address = {Heidelberg},
publisher = {Springer},
reportid = {DZNE-2025-00004},
pages = {90},
year = {2025},
abstract = {Non-motor symptoms frequently develop throughout the
disease course of Parkinson's disease (PD), and pose
affected individuals at risk of complications, more rapid
disease progression and poorer quality of life. Addressing
such symptom burden, the 2023 revised 'Parkinson's disease'
guideline of the German Society of Neurology aimed at
providing evidence-based recommendations for managing PD
non-motor symptoms, including autonomic failure, pain and
sleep disturbances.Key PICO (Patient, Intervention,
Comparison, Outcome) questions were formulated by the
steering committee and refined by the assigned authors.
Recommendations were drafted based on relevant studies,
systematic reviews, meta-analyses and high-quality
guidelines identified by the literature search. They were
subsequently reviewed, revised, and voted by the Guideline
Group in online consensus conferences. Consensus was
achieved in case of > $75\%$ agreement among the group
members. The consensus was considered strong, if agreement
was > $95\%.The$ guideline entails: (i) 10 PICOs and 23
recommendations on the diagnosis and treatment of
urogenital, cardiovascular and gastrointestinal autonomic
failure; (ii) four PICOs and four recommendations on the
possible types of pain in PD individuals, their diagnosis
and treatment; (iii) 11 PICOs and 11 recommendations on the
screening, diagnosis and treatment of sleep disturbances and
excessive daytime sleepiness in PD individuals, as well as
on their prognostic implications. Thirty-one out of 38
recommendations achieved a strong consensus.The current
German PD guideline provides a practice-oriented and
etiology-driven stepwise approach to the diagnosis and
treatment of autonomic failure, pain and sleep disturbances
in PD individuals.},
subtyp = {Review Article},
keywords = {Humans / Parkinson Disease: complications / Parkinson
Disease: diagnosis / Parkinson Disease: therapy / Sleep Wake
Disorders: etiology / Sleep Wake Disorders: therapy / Sleep
Wake Disorders: diagnosis / Germany / Pain: etiology / Pain:
diagnosis / Autonomic Nervous System Diseases: etiology /
Autonomic Nervous System Diseases: diagnosis / Autonomic
Nervous System Diseases: therapy / Neurology: standards /
Societies, Medical: standards / Constipation (Other) /
Daytime sleepiness (Other) / Erectile dysfunction (Other) /
Nocturia (Other) / Orthostatic hypotension (Other) / Pain
(Other) / Parkinson’s disease (Other) / REM-sleep behavior
disorder (Other) / Sleep (Other) / Supine hypertension
(Other) / Urinary incontinence (Other)},
cin = {Clinical Research (Munich) / AG Storch},
ddc = {610},
cid = {I:(DE-2719)1111015 / I:(DE-2719)5000014},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:39751950},
pmc = {pmc:PMC11698777},
doi = {10.1007/s00415-024-12730-5},
url = {https://pub.dzne.de/record/274023},
}