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000274029 041__ $$aEnglish
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000274029 1001_ $$0P:(DE-2719)2810557$$aBernis, Maria E$$b0$$eFirst author$$udzne
000274029 245__ $$aThe Neuroprotective Effects of Caffeine in a Neonatal Hypoxia-Ischemia Model are Regulated through the AMPK/mTOR Pathway.
000274029 260__ $$aLake Haven, N.S.W. [u.a.]$$bIvyspring International Publ.$$c2025
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000274029 520__ $$aNeonatal hypoxic-ischemic encephalopathy (HIE) is the most common cause of death and long-term disabilities in term neonates. Caffeine exerts anti-inflammatory effects and has been used in neonatal intensive care units in recent decades. In our neonatal rat model of hypoxic-ischemic (HI) brain injury, we demonstrated that a single daily dose of caffeine (40 mg/kg) for 3 days post-HI reduced brain tissue loss and microgliosis compared to the vehicle group. The AMPK/mTOR pathway plays an important role in sensing the stress responses following brain injury. However, the role of mTOR in HI-associated brain damage remains unclear. A detailed analysis of the AMPK/mTOR pathway in our model revealed that this pathway plays a key role in hypoxia-regulated neuroprotection and can be significantly influenced by caffeine treatment. Targeting HI with caffeine might offer effective neuroprotection, reduce mortality, and improve functional outcomes in patients with HIE, especially in low- and middle-income countries, where neuroprotective treatment is urgently needed.
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000274029 650_7 $$2Other$$aAMPK
000274029 650_7 $$2Other$$aCaffeine
000274029 650_7 $$2Other$$aHypoxia-Ischemia
000274029 650_7 $$2Other$$aNeonatal
000274029 650_7 $$2Other$$aNeuroprotection
000274029 650_7 $$2Other$$amTOR
000274029 650_7 $$03G6A5W338E$$2NLM Chemicals$$aCaffeine
000274029 650_7 $$2NLM Chemicals$$aNeuroprotective Agents
000274029 650_7 $$0EC 2.7.11.1$$2NLM Chemicals$$aTOR Serine-Threonine Kinases
000274029 650_7 $$0EC 2.7.11.31$$2NLM Chemicals$$aAMP-Activated Protein Kinases
000274029 650_2 $$2MeSH$$aCaffeine: pharmacology
000274029 650_2 $$2MeSH$$aCaffeine: therapeutic use
000274029 650_2 $$2MeSH$$aAnimals
000274029 650_2 $$2MeSH$$aNeuroprotective Agents: therapeutic use
000274029 650_2 $$2MeSH$$aNeuroprotective Agents: pharmacology
000274029 650_2 $$2MeSH$$aTOR Serine-Threonine Kinases: metabolism
000274029 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: metabolism
000274029 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: drug therapy
000274029 650_2 $$2MeSH$$aRats
000274029 650_2 $$2MeSH$$aAnimals, Newborn
000274029 650_2 $$2MeSH$$aRats, Sprague-Dawley
000274029 650_2 $$2MeSH$$aAMP-Activated Protein Kinases: metabolism
000274029 650_2 $$2MeSH$$aSignal Transduction: drug effects
000274029 650_2 $$2MeSH$$aDisease Models, Animal
000274029 7001_ $$0P:(DE-2719)9002524$$aBurkard, Hannah$$b1$$udzne
000274029 7001_ $$0P:(DE-2719)9001591$$aBremer, Anna-Sophie$$b2$$udzne
000274029 7001_ $$0P:(DE-2719)9003296$$aGrzelak, Kora$$b3$$udzne
000274029 7001_ $$0P:(DE-2719)9000835$$aZweyer, Margit$$b4$$udzne
000274029 7001_ $$0P:(DE-2719)9001055$$aMaes, Elke$$b5$$udzne
000274029 7001_ $$0P:(DE-2719)9002544$$aNacarkucuk, Efe$$b6$$udzne
000274029 7001_ $$0P:(DE-2719)9001619$$aKaibel, Hanna$$b7$$udzne
000274029 7001_ $$0P:(DE-2719)9002687$$aHakvoort, Charlotte$$b8$$udzne
000274029 7001_ $$aMüller, Andreas$$b9
000274029 7001_ $$0P:(DE-2719)9000732$$aSabir, Hemmen$$b10$$eLast author$$udzne
000274029 773__ $$0PERI:(DE-600)2179208-2$$a10.7150/ijbs.101087$$gVol. 21, no. 1, p. 251 - 270$$n1$$p251 - 270$$tInternational journal of biological sciences$$v21$$x1449-2288$$y2025
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