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000274034 041__ $$aEnglish
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000274034 1001_ $$00000-0002-5663-9407$$aFang, Rong$$b0
000274034 245__ $$aRisk factors and clinical significance of post-stroke incident ischemic lesions.
000274034 260__ $$aHoboken, NJ$$bWiley$$c2024
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000274034 520__ $$aWhile incident ischemic lesions (IILs) are not unusual on follow-up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.In a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.At 6 months, 78 patients (15.5%) had IILs, mostly diffusion-weighted imaging-positive (72%) and clinically covert (91%). Older age and small vessel disease (SVD) lesions were baseline risk factors for IILs. IILs were associated with worse cognitive (beta for global cognition: -0.31, 95% confidence interval [CI]: -0.48 to -0.14) and functional outcomes (beta for modified Rankin scale [mRS]: 0.36, 95% CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard ratio: 3.81, 95% CI: 1.35 to 10.69). IILs partially explained the relationship between SVD and poor cognition.IILs are common and are associated with worse cognitive and functional outcomes and stroke recurrence risk. Assessing IILs following stroke might aid prognostication.Incident ischemic lesions (IILs) were assessed with registered baseline and 6-month magnetic resonance imaging (MRI) scans in a stroke cohort. IILs 6 months after stroke are present in one-sixth of patients and are mostly clinically silent. Small vessel disease burden is the main baseline risk factor for IILs. IILs are associated with cognitive and functional impairment and stroke recurrence. Assessing IILs by follow-up MRI aids long-term prognostication for stroke patients.
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000274034 650_7 $$2Other$$acerebral small vessel disease
000274034 650_7 $$2Other$$acognitive impairment
000274034 650_7 $$2Other$$afunctional outcome
000274034 650_7 $$2Other$$aincident ischemic lesions
000274034 650_7 $$2Other$$arecurrent stroke
000274034 650_7 $$2Other$$astroke
000274034 650_2 $$2MeSH$$aHumans
000274034 650_2 $$2MeSH$$aMale
000274034 650_2 $$2MeSH$$aFemale
000274034 650_2 $$2MeSH$$aRisk Factors
000274034 650_2 $$2MeSH$$aAged
000274034 650_2 $$2MeSH$$aProspective Studies
000274034 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000274034 650_2 $$2MeSH$$aStroke: epidemiology
000274034 650_2 $$2MeSH$$aStroke: diagnostic imaging
000274034 650_2 $$2MeSH$$aStroke: complications
000274034 650_2 $$2MeSH$$aBrain Ischemia: diagnostic imaging
000274034 650_2 $$2MeSH$$aBrain Ischemia: complications
000274034 650_2 $$2MeSH$$aMiddle Aged
000274034 650_2 $$2MeSH$$aPrognosis
000274034 650_2 $$2MeSH$$aIschemic Stroke: diagnostic imaging
000274034 650_2 $$2MeSH$$aIschemic Stroke: epidemiology
000274034 650_2 $$2MeSH$$aDiffusion Magnetic Resonance Imaging
000274034 650_2 $$2MeSH$$aBrain: diagnostic imaging
000274034 650_2 $$2MeSH$$aBrain: pathology
000274034 650_2 $$2MeSH$$aClinical Relevance
000274034 7001_ $$aDuering, Marco$$b1
000274034 7001_ $$0P:(DE-2719)2811949$$aBode, Felix J$$b2$$udzne
000274034 7001_ $$0P:(DE-2719)9000778$$aStoesser, Sebastian$$b3$$udzne
000274034 7001_ $$0P:(DE-HGF)0$$aMeißner, Julius N$$b4
000274034 7001_ $$0P:(DE-2719)2812183$$aHermann, Peter$$b5
000274034 7001_ $$0P:(DE-2719)9000189$$aLiman, Thomas G$$b6$$udzne
000274034 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b7
000274034 7001_ $$0P:(DE-2719)2811628$$aKerti, Lucia$$b8$$udzne
000274034 7001_ $$aIkenberg, Benno$$b9
000274034 7001_ $$aBernkopf, Kathleen$$b10
000274034 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b11$$udzne
000274034 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b12$$udzne
000274034 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b13$$udzne
000274034 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b14$$udzne
000274034 7001_ $$0P:(DE-2719)2810706$$aSpeck, Oliver$$b15$$udzne
000274034 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b16$$udzne
000274034 7001_ $$0P:(DE-2719)9001112$$aGesierich, Benno$$b17$$udzne
000274034 7001_ $$aDewenter, Anna$$b18
000274034 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b19$$udzne
000274034 7001_ $$0P:(DE-2719)2814124$$aWaegemann, Karin$$b20
000274034 7001_ $$0P:(DE-2719)2811292$$aGörtler, Michael$$b21
000274034 7001_ $$aWunderlich, Silke$$b22
000274034 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b23$$udzne
000274034 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b24$$udzne
000274034 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b25
000274034 7001_ $$aGeorgakis, Marios K$$b26
000274034 7001_ $$0P:(DE-2719)2000030$$aDichgans, Martin$$b27$$eLast author$$udzne
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000274034 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14274$$gVol. 20, no. 12, p. 8412 - 8428$$n12$$p8412 - 8428$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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