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@ARTICLE{Fang:274034,
      author       = {Fang, Rong and Duering, Marco and Bode, Felix J and
                      Stoesser, Sebastian and Meißner, Julius N and Hermann,
                      Peter and Liman, Thomas G and Nolte, Christian and Kerti,
                      Lucia and Ikenberg, Benno and Bernkopf, Kathleen and Glanz,
                      Wenzel and Janowitz, Daniel and Wagner, Michael and Neumann,
                      Katja and Speck, Oliver and Düzel, Emrah and Gesierich,
                      Benno and Dewenter, Anna and Spottke, Annika and Waegemann,
                      Karin and Görtler, Michael and Wunderlich, Silke and Zerr,
                      Inga and Petzold, Gabor C and Endres, Matthias and
                      Georgakis, Marios K and Dichgans, Martin},
      collaboration = {investigators, DEMDAS},
      title        = {{R}isk factors and clinical significance of post-stroke
                      incident ischemic lesions.},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {12},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00015},
      pages        = {8412 - 8428},
      year         = {2024},
      abstract     = {While incident ischemic lesions (IILs) are not unusual on
                      follow-up magnetic resonance imaging (MRI) following stroke,
                      their risk factors and prognostic significance remain
                      unknown.In a prospective multicenter study of 503 acute
                      stroke patients, we assessed IILs on registered MRI images
                      at baseline and 6 months, analyzing risk factors and
                      clinical outcomes across 36 months.At 6 months, 78 patients
                      $(15.5\%)$ had IILs, mostly diffusion-weighted
                      imaging-positive $(72\%)$ and clinically covert $(91\%).$
                      Older age and small vessel disease (SVD) lesions were
                      baseline risk factors for IILs. IILs were associated with
                      worse cognitive (beta for global cognition: -0.31, $95\%$
                      confidence interval [CI]: -0.48 to -0.14) and functional
                      outcomes (beta for modified Rankin scale [mRS]: 0.36, $95\%$
                      CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard
                      ratio: 3.81, $95\%$ CI: 1.35 to 10.69). IILs partially
                      explained the relationship between SVD and poor
                      cognition.IILs are common and are associated with worse
                      cognitive and functional outcomes and stroke recurrence
                      risk. Assessing IILs following stroke might aid
                      prognostication.Incident ischemic lesions (IILs) were
                      assessed with registered baseline and 6-month magnetic
                      resonance imaging (MRI) scans in a stroke cohort. IILs 6
                      months after stroke are present in one-sixth of patients and
                      are mostly clinically silent. Small vessel disease burden is
                      the main baseline risk factor for IILs. IILs are associated
                      with cognitive and functional impairment and stroke
                      recurrence. Assessing IILs by follow-up MRI aids long-term
                      prognostication for stroke patients.},
      keywords     = {Humans / Male / Female / Risk Factors / Aged / Prospective
                      Studies / Magnetic Resonance Imaging / Stroke: epidemiology
                      / Stroke: diagnostic imaging / Stroke: complications / Brain
                      Ischemia: diagnostic imaging / Brain Ischemia: complications
                      / Middle Aged / Prognosis / Ischemic Stroke: diagnostic
                      imaging / Ischemic Stroke: epidemiology / Diffusion Magnetic
                      Resonance Imaging / Brain: diagnostic imaging / Brain:
                      pathology / Clinical Relevance / cerebral small vessel
                      disease (Other) / cognitive impairment (Other) / functional
                      outcome (Other) / incident ischemic lesions (Other) /
                      recurrent stroke (Other) / stroke (Other)},
      cin          = {AG Dichgans / AG Petzold / Clinical Research (Bonn) / AG
                      Endres / AG Düzel / AG Wagner / AG Speck / AG Spottke / AG
                      Zerr},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022 / I:(DE-2719)1013020 /
                      I:(DE-2719)1011001 / I:(DE-2719)1811005 / I:(DE-2719)5000006
                      / I:(DE-2719)1011201 / I:(DE-2719)1340009 /
                      I:(DE-2719)1011103 / I:(DE-2719)1440011-1},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39417418},
      pmc          = {pmc:PMC11667539},
      doi          = {10.1002/alz.14274},
      url          = {https://pub.dzne.de/record/274034},
}