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001     274034
005     20260212171421.0
024 7 _ |2 doi
|a 10.1002/alz.14274
024 7 _ |2 pmid
|a pmid:39417418
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|a pmc:PMC11667539
024 7 _ |2 ISSN
|a 1552-5260
024 7 _ |2 ISSN
|a 1552-5279
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|a altmetric:169438242
037 _ _ |a DZNE-2025-00015
041 _ _ |a English
082 _ _ |a 610
100 1 _ |0 0000-0002-5663-9407
|a Fang, Rong
|b 0
245 _ _ |a Risk factors and clinical significance of post-stroke incident ischemic lesions.
260 _ _ |a Hoboken, NJ
|b Wiley
|c 2024
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|a Journal Article
520 _ _ |a While incident ischemic lesions (IILs) are not unusual on follow-up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown.In a prospective multicenter study of 503 acute stroke patients, we assessed IILs on registered MRI images at baseline and 6 months, analyzing risk factors and clinical outcomes across 36 months.At 6 months, 78 patients (15.5%) had IILs, mostly diffusion-weighted imaging-positive (72%) and clinically covert (91%). Older age and small vessel disease (SVD) lesions were baseline risk factors for IILs. IILs were associated with worse cognitive (beta for global cognition: -0.31, 95% confidence interval [CI]: -0.48 to -0.14) and functional outcomes (beta for modified Rankin scale [mRS]: 0.36, 95% CI: 0.14 to 0.58), and higher recurrent stroke risk (hazard ratio: 3.81, 95% CI: 1.35 to 10.69). IILs partially explained the relationship between SVD and poor cognition.IILs are common and are associated with worse cognitive and functional outcomes and stroke recurrence risk. Assessing IILs following stroke might aid prognostication.Incident ischemic lesions (IILs) were assessed with registered baseline and 6-month magnetic resonance imaging (MRI) scans in a stroke cohort. IILs 6 months after stroke are present in one-sixth of patients and are mostly clinically silent. Small vessel disease burden is the main baseline risk factor for IILs. IILs are associated with cognitive and functional impairment and stroke recurrence. Assessing IILs by follow-up MRI aids long-term prognostication for stroke patients.
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650 _ 7 |2 Other
|a cerebral small vessel disease
650 _ 7 |2 Other
|a cognitive impairment
650 _ 7 |2 Other
|a functional outcome
650 _ 7 |2 Other
|a incident ischemic lesions
650 _ 7 |2 Other
|a recurrent stroke
650 _ 7 |2 Other
|a stroke
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Risk Factors
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Prospective Studies
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Stroke: epidemiology
650 _ 2 |2 MeSH
|a Stroke: diagnostic imaging
650 _ 2 |2 MeSH
|a Stroke: complications
650 _ 2 |2 MeSH
|a Brain Ischemia: diagnostic imaging
650 _ 2 |2 MeSH
|a Brain Ischemia: complications
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Prognosis
650 _ 2 |2 MeSH
|a Ischemic Stroke: diagnostic imaging
650 _ 2 |2 MeSH
|a Ischemic Stroke: epidemiology
650 _ 2 |2 MeSH
|a Diffusion Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Brain: diagnostic imaging
650 _ 2 |2 MeSH
|a Brain: pathology
650 _ 2 |2 MeSH
|a Clinical Relevance
700 1 _ |a Duering, Marco
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773 _ _ |0 PERI:(DE-600)2201940-6
|a 10.1002/alz.14274
|g Vol. 20, no. 12, p. 8412 - 8428
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