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000274035 0247_ $$2doi$$a10.1002/alz.14344
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000274035 037__ $$aDZNE-2025-00016
000274035 041__ $$aEnglish
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000274035 1001_ $$aUdeh-Momoh, Chinedu T$$b0
000274035 245__ $$aDementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).
000274035 260__ $$aHoboken, NJ$$bWiley$$c2024
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000274035 520__ $$aDementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent. HIGHLIGHTS: Dementia rates are escalating in Africa, largely due to longer life spans and increased prevalence of modifiable risk factors. Yet, few regional interventions have directly targeted lifestyle factors to reduce dementia risk. The multinational Africa-FINGERS study will address this gap by adapting the successful FINGERS lifestyle intervention to African populations. Africa-FINGERS will pioneer a culturally informed, multidomain dementia risk reduction intervention in the African region through feasibility dementia prevention trials in rural and urban sites across Kenya and Nigeria in the first instance, enrolling 600 at-risk adults (≥ 50 years). The program adopts participatory research methods to develop culturally appropriate interventions and build infrastructure to evaluate dementia biomarkers from ante and post mortem samples. A cost-effectiveness analysis will be conducted to guide the strategic implementation of Africa-FINGERS into regional health systems. The Africa-FINGERS strategy aligns with the Worldwide-FINGERS framework and integrates the global Alzheimer's Disease Neuroimaging Initiative approach, emphasizing multimodal analysis.
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000274035 650_7 $$2Other$$aAlzheimer's disease
000274035 650_7 $$2Other$$abrain banking
000274035 650_7 $$2Other$$acommunity‐based participatory research
000274035 650_7 $$2Other$$adementia prevention trials
000274035 650_7 $$2Other$$afluid and neuroimaging biomarkers
000274035 650_7 $$2Other$$ahealth economics
000274035 650_7 $$2Other$$aimplementation science
000274035 650_7 $$2Other$$aretinal imaging
000274035 650_2 $$2MeSH$$aHumans
000274035 650_2 $$2MeSH$$aRisk Reduction Behavior
000274035 650_2 $$2MeSH$$aAfrica: epidemiology
000274035 650_2 $$2MeSH$$aDementia: prevention & control
000274035 650_2 $$2MeSH$$aDementia: epidemiology
000274035 650_2 $$2MeSH$$aBrain
000274035 650_2 $$2MeSH$$aRisk Factors
000274035 650_2 $$2MeSH$$aHealthy Aging
000274035 650_2 $$2MeSH$$aNeuroimaging
000274035 7001_ $$aMaina, Rachel$$b1
000274035 7001_ $$aAnazodo, Udunna C$$b2
000274035 7001_ $$aAkinyemi, Rufus$$b3
000274035 7001_ $$aAtwoli, Lukoye$$b4
000274035 7001_ $$aBaker, Laura$$b5
000274035 7001_ $$aBassil, Darina$$b6
000274035 7001_ $$aBlackmon, Karen$$b7
000274035 7001_ $$aBosire, Edna$$b8
000274035 7001_ $$aChemutai, Gloria$$b9
000274035 7001_ $$aCrivelli, Lucia$$b10
000274035 7001_ $$aEze, Laz U$$b11
000274035 7001_ $$aIbanez, Agustin$$b12
000274035 7001_ $$aKafetsouli, Dimitra$$b13
000274035 7001_ $$aKarikari, Thomas K$$b14
000274035 7001_ $$aKhakali, Linda$$b15
000274035 7001_ $$aKumar, Manasi$$b16
000274035 7001_ $$aLengyel, Imre$$b17
000274035 7001_ $$ade Jager Loots, Celeste A$$b18
000274035 7001_ $$aMangialasche, Francesca$$b19
000274035 7001_ $$aMbugua, Sylvia$$b20
000274035 7001_ $$aMerali, Zul$$b21
000274035 7001_ $$aMielke, Michelle$$b22
000274035 7001_ $$aMostert, Cyprian$$b23
000274035 7001_ $$aMuthoni, Eunice$$b24
000274035 7001_ $$aNesic-Taylor, Olivera$$b25
000274035 7001_ $$aNgugi, Anthony$$b26
000274035 7001_ $$aNguku, Samuel$$b27
000274035 7001_ $$aOgunniyi, Adesola$$b28
000274035 7001_ $$aOgunyemi, Adedoyin$$b29
000274035 7001_ $$aOkonkwo, Ozioma C$$b30
000274035 7001_ $$aOkubadejo, Njideka$$b31
000274035 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b32$$udzne
000274035 7001_ $$aPeto, Tunde$$b33
000274035 7001_ $$aRiang'a, Roselyter M$$b34
000274035 7001_ $$aSaleh, Mansoor$$b35
000274035 7001_ $$aSayed, Shaheen$$b36
000274035 7001_ $$aShah, Jasmit$$b37
000274035 7001_ $$aShah, Sheena$$b38
000274035 7001_ $$aSolomon, Alina$$b39
000274035 7001_ $$aThesen, Thomas$$b40
000274035 7001_ $$aTrepel, Dominic$$b41
000274035 7001_ $$aUcheagwu, Valentine$$b42
000274035 7001_ $$aValcour, Victor$$b43
000274035 7001_ $$aWaa, Sheila$$b44
000274035 7001_ $$aWatermeyer, Tamlyn$$b45
000274035 7001_ $$aYokoyama, Jennifer$$b46
000274035 7001_ $$aZetterberg, Henrik$$b47
000274035 7001_ $$aKivipelto, Miia$$b48
000274035 7001_ $$aTeam, Africa-FINGERS Study$$b49$$eCollaboration Author
000274035 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14344$$gVol. 20, no. 12, p. 8987 - 9003$$n12$$p8987 - 9003$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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