TY  - JOUR
AU  - Udeh-Momoh, Chinedu T
AU  - Maina, Rachel
AU  - Anazodo, Udunna C
AU  - Akinyemi, Rufus
AU  - Atwoli, Lukoye
AU  - Baker, Laura
AU  - Bassil, Darina
AU  - Blackmon, Karen
AU  - Bosire, Edna
AU  - Chemutai, Gloria
AU  - Crivelli, Lucia
AU  - Eze, Laz U
AU  - Ibanez, Agustin
AU  - Kafetsouli, Dimitra
AU  - Karikari, Thomas K
AU  - Khakali, Linda
AU  - Kumar, Manasi
AU  - Lengyel, Imre
AU  - de Jager Loots, Celeste A
AU  - Mangialasche, Francesca
AU  - Mbugua, Sylvia
AU  - Merali, Zul
AU  - Mielke, Michelle
AU  - Mostert, Cyprian
AU  - Muthoni, Eunice
AU  - Nesic-Taylor, Olivera
AU  - Ngugi, Anthony
AU  - Nguku, Samuel
AU  - Ogunniyi, Adesola
AU  - Ogunyemi, Adedoyin
AU  - Okonkwo, Ozioma C
AU  - Okubadejo, Njideka
AU  - Perneczky, Robert
AU  - Peto, Tunde
AU  - Riang'a, Roselyter M
AU  - Saleh, Mansoor
AU  - Sayed, Shaheen
AU  - Shah, Jasmit
AU  - Shah, Sheena
AU  - Solomon, Alina
AU  - Thesen, Thomas
AU  - Trepel, Dominic
AU  - Ucheagwu, Valentine
AU  - Valcour, Victor
AU  - Waa, Sheila
AU  - Watermeyer, Tamlyn
AU  - Yokoyama, Jennifer
AU  - Zetterberg, Henrik
AU  - Kivipelto, Miia
TI  - Dementia risk reduction in the African context: Multi-national implementation of multimodal strategies to promote healthy brain aging in Africa (the Africa-FINGERS project).
JO  - Alzheimer's and dementia
VL  - 20
IS  - 12
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00016
SP  - 8987 - 9003
PY  - 2024
AB  - Dementia prevention in Africa is critically underexplored, despite the continent's high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region. Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer's Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent. HIGHLIGHTS: Dementia rates are escalating in Africa, largely due to longer life spans and increased prevalence of modifiable risk factors. Yet, few regional interventions have directly targeted lifestyle factors to reduce dementia risk. The multinational Africa-FINGERS study will address this gap by adapting the successful FINGERS lifestyle intervention to African populations. Africa-FINGERS will pioneer a culturally informed, multidomain dementia risk reduction intervention in the African region through feasibility dementia prevention trials in rural and urban sites across Kenya and Nigeria in the first instance, enrolling 600 at-risk adults (≥ 50 years). The program adopts participatory research methods to develop culturally appropriate interventions and build infrastructure to evaluate dementia biomarkers from ante and post mortem samples. A cost-effectiveness analysis will be conducted to guide the strategic implementation of Africa-FINGERS into regional health systems. The Africa-FINGERS strategy aligns with the Worldwide-FINGERS framework and integrates the global Alzheimer's Disease Neuroimaging Initiative approach, emphasizing multimodal analysis.
KW  - Humans
KW  - Risk Reduction Behavior
KW  - Africa: epidemiology
KW  - Dementia: prevention & control
KW  - Dementia: epidemiology
KW  - Brain
KW  - Risk Factors
KW  - Healthy Aging
KW  - Neuroimaging
KW  - Alzheimer's disease (Other)
KW  - brain banking (Other)
KW  - community‐based participatory research (Other)
KW  - dementia prevention trials (Other)
KW  - fluid and neuroimaging biomarkers (Other)
KW  - health economics (Other)
KW  - implementation science (Other)
KW  - retinal imaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39511921
C2  - pmc:PMC11667543
DO  - DOI:10.1002/alz.14344
UR  - https://pub.dzne.de/record/274035
ER  -