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@ARTICLE{UdehMomoh:274035,
      author       = {Udeh-Momoh, Chinedu T and Maina, Rachel and Anazodo, Udunna
                      C and Akinyemi, Rufus and Atwoli, Lukoye and Baker, Laura
                      and Bassil, Darina and Blackmon, Karen and Bosire, Edna and
                      Chemutai, Gloria and Crivelli, Lucia and Eze, Laz U and
                      Ibanez, Agustin and Kafetsouli, Dimitra and Karikari, Thomas
                      K and Khakali, Linda and Kumar, Manasi and Lengyel, Imre and
                      de Jager Loots, Celeste A and Mangialasche, Francesca and
                      Mbugua, Sylvia and Merali, Zul and Mielke, Michelle and
                      Mostert, Cyprian and Muthoni, Eunice and Nesic-Taylor,
                      Olivera and Ngugi, Anthony and Nguku, Samuel and Ogunniyi,
                      Adesola and Ogunyemi, Adedoyin and Okonkwo, Ozioma C and
                      Okubadejo, Njideka and Perneczky, Robert and Peto, Tunde and
                      Riang'a, Roselyter M and Saleh, Mansoor and Sayed, Shaheen
                      and Shah, Jasmit and Shah, Sheena and Solomon, Alina and
                      Thesen, Thomas and Trepel, Dominic and Ucheagwu, Valentine
                      and Valcour, Victor and Waa, Sheila and Watermeyer, Tamlyn
                      and Yokoyama, Jennifer and Zetterberg, Henrik and Kivipelto,
                      Miia},
      collaboration = {Team, Africa-FINGERS Study},
      title        = {{D}ementia risk reduction in the {A}frican context:
                      {M}ulti-national implementation of multimodal strategies to
                      promote healthy brain aging in {A}frica (the
                      {A}frica-{FINGERS} project).},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {12},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-00016},
      pages        = {8987 - 9003},
      year         = {2024},
      abstract     = {Dementia prevention in Africa is critically underexplored,
                      despite the continent's high prevalence of modifiable risk
                      factors. With a predominantly young and middle-aged
                      population, Africa presents a prime opportunity to implement
                      evidence-based strategies that could significantly reduce
                      future dementia cases and mitigate its economic impact. The
                      multinational Africa-FINGERS program offers an innovative
                      solution, pioneering culturally sensitive, multidomain
                      interventions tailored to the unique challenges of the
                      region. Leveraging insights from landmark global studies
                      such as Worldwide-FINGERS and Alzheimer's Disease
                      Neuroimaging Initiative, the program employs a
                      multideterminant precision prevention framework, grounded in
                      community based systems dynamics. Africa-FINGERS further
                      integrates cutting-edge state-of-the-art multimodal
                      biomarker evaluations tailored to regional contexts, with
                      the goal of advancing brain health and establishing a global
                      standard for dementia prevention. This groundbreaking
                      initiative highlights the potential for scalableand
                      sustainable interventions, thus is poised to transform
                      dementia risk reduction efforts across the continent.
                      HIGHLIGHTS: Dementia rates are escalating in Africa, largely
                      due to longer life spans and increased prevalence of
                      modifiable risk factors. Yet, few regional interventions
                      have directly targeted lifestyle factors to reduce dementia
                      risk. The multinational Africa-FINGERS study will address
                      this gap by adapting the successful FINGERS lifestyle
                      intervention to African populations. Africa-FINGERS will
                      pioneer a culturally informed, multidomain dementia risk
                      reduction intervention in the African region through
                      feasibility dementia prevention trials in rural and urban
                      sites across Kenya and Nigeria in the first instance,
                      enrolling 600 at-risk adults (≥ 50 years). The program
                      adopts participatory research methods to develop culturally
                      appropriate interventions and build infrastructure to
                      evaluate dementia biomarkers from ante and post mortem
                      samples. A cost-effectiveness analysis will be conducted to
                      guide the strategic implementation of Africa-FINGERS into
                      regional health systems. The Africa-FINGERS strategy aligns
                      with the Worldwide-FINGERS framework and integrates the
                      global Alzheimer's Disease Neuroimaging Initiative approach,
                      emphasizing multimodal analysis.},
      keywords     = {Humans / Risk Reduction Behavior / Africa: epidemiology /
                      Dementia: prevention $\&$ control / Dementia: epidemiology /
                      Brain / Risk Factors / Healthy Aging / Neuroimaging /
                      Alzheimer's disease (Other) / brain banking (Other) /
                      community‐based participatory research (Other) / dementia
                      prevention trials (Other) / fluid and neuroimaging
                      biomarkers (Other) / health economics (Other) /
                      implementation science (Other) / retinal imaging (Other)},
      cin          = {AG Dichgans},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39511921},
      pmc          = {pmc:PMC11667543},
      doi          = {10.1002/alz.14344},
      url          = {https://pub.dzne.de/record/274035},
}