%0 Journal Article
%A Göschel, Laura
%A Dell Orco, Andrea
%A Fillmer, Ariane
%A Aydin, Semiha
%A Ittermann, Bernd
%A Riemann, Layla
%A Lehmann, Sylvain
%A Cano, Stefan
%A Melin, Jeanette
%A Pendrill, Leslie
%A Hoede, Patty L
%A Teunissen, Charlotte E
%A Schwarz, Claudia
%A Grittner, Ulrike
%A Körtvelyessy, Peter
%A Flöel, Agnes
%T Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS.
%J Alzheimer's and dementia
%V 20
%N 12
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M DZNE-2025-00017
%P 8684 - 8699
%D 2024
%X Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer's disease (AD) remain unclear.In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models.Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol.Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively.This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
%K Humans
%K Alzheimer Disease: blood
%K Alzheimer Disease: pathology
%K Alzheimer Disease: diagnostic imaging
%K tau Proteins: blood
%K Female
%K Longitudinal Studies
%K Male
%K Aged
%K Magnetic Resonance Imaging
%K Glial Fibrillary Acidic Protein: blood
%K Biomarkers: blood
%K Magnetic Resonance Spectroscopy
%K Brain: diagnostic imaging
%K Brain: pathology
%K Amyloid beta-Peptides: blood
%K Phosphorylation
%K Disease Progression
%K Middle Aged
%K Neurofilament Proteins: blood
%K 7 Tesla (Other)
%K Alzheimer's disease (Other)
%K NeuroMET Memory Metric (Other)
%K amyloid beta 42/40 (Other)
%K blood‐based biomarkers (Other)
%K functional magnetic resonance imaging (Other)
%K glial fibrillary acidic protein (Other)
%K magnetic resonance imaging (Other)
%K magnetic resonance spectroscopy (Other)
%K memory (Other)
%K mild cognitive impairment (Other)
%K neurofilament light chain (Other)
%K plasma biomarkers (Other)
%K subjective cognitive decline (Other)
%K tau phosphorylated at threonine 181 (Other)
%K tau Proteins (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39558898
%2 pmc:PMC11667506
%R 10.1002/alz.14318
%U https://pub.dzne.de/record/274036