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000274036 0247_ $$2doi$$a10.1002/alz.14318
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000274036 041__ $$aEnglish
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000274036 1001_ $$00000-0001-6592-2493$$aGöschel, Laura$$b0
000274036 245__ $$aPlasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS.
000274036 260__ $$aHoboken, NJ$$bWiley$$c2024
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000274036 520__ $$aAssociations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer's disease (AD) remain unclear.In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models.Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol.Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively.This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
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000274036 650_7 $$2Other$$a7 Tesla
000274036 650_7 $$2Other$$aAlzheimer's disease
000274036 650_7 $$2Other$$aNeuroMET Memory Metric
000274036 650_7 $$2Other$$aamyloid beta 42/40
000274036 650_7 $$2Other$$ablood‐based biomarkers
000274036 650_7 $$2Other$$afunctional magnetic resonance imaging
000274036 650_7 $$2Other$$aglial fibrillary acidic protein
000274036 650_7 $$2Other$$amagnetic resonance imaging
000274036 650_7 $$2Other$$amagnetic resonance spectroscopy
000274036 650_7 $$2Other$$amemory
000274036 650_7 $$2Other$$amild cognitive impairment
000274036 650_7 $$2Other$$aneurofilament light chain
000274036 650_7 $$2Other$$aplasma biomarkers
000274036 650_7 $$2Other$$asubjective cognitive decline
000274036 650_7 $$2Other$$atau phosphorylated at threonine 181
000274036 650_7 $$2NLM Chemicals$$atau Proteins
000274036 650_7 $$2NLM Chemicals$$aGlial Fibrillary Acidic Protein
000274036 650_7 $$2NLM Chemicals$$aBiomarkers
000274036 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000274036 650_7 $$2NLM Chemicals$$aGFAP protein, human
000274036 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000274036 650_2 $$2MeSH$$aHumans
000274036 650_2 $$2MeSH$$aAlzheimer Disease: blood
000274036 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000274036 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000274036 650_2 $$2MeSH$$atau Proteins: blood
000274036 650_2 $$2MeSH$$aFemale
000274036 650_2 $$2MeSH$$aLongitudinal Studies
000274036 650_2 $$2MeSH$$aMale
000274036 650_2 $$2MeSH$$aAged
000274036 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000274036 650_2 $$2MeSH$$aGlial Fibrillary Acidic Protein: blood
000274036 650_2 $$2MeSH$$aBiomarkers: blood
000274036 650_2 $$2MeSH$$aMagnetic Resonance Spectroscopy
000274036 650_2 $$2MeSH$$aBrain: diagnostic imaging
000274036 650_2 $$2MeSH$$aBrain: pathology
000274036 650_2 $$2MeSH$$aAmyloid beta-Peptides: blood
000274036 650_2 $$2MeSH$$aPhosphorylation
000274036 650_2 $$2MeSH$$aDisease Progression
000274036 650_2 $$2MeSH$$aMiddle Aged
000274036 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000274036 7001_ $$0P:(DE-2719)9001684$$aDell Orco, Andrea$$b1$$udzne
000274036 7001_ $$00000-0003-3333-6603$$aFillmer, Ariane$$b2
000274036 7001_ $$aAydin, Semiha$$b3
000274036 7001_ $$00000-0002-4087-471X$$aIttermann, Bernd$$b4
000274036 7001_ $$00000-0001-5411-7288$$aRiemann, Layla$$b5
000274036 7001_ $$00000-0001-6117-562X$$aLehmann, Sylvain$$b6
000274036 7001_ $$00000-0001-9390-273X$$aCano, Stefan$$b7
000274036 7001_ $$00000-0002-3700-3921$$aMelin, Jeanette$$b8
000274036 7001_ $$00000-0003-4349-500X$$aPendrill, Leslie$$b9
000274036 7001_ $$00000-0003-3733-2845$$aHoede, Patty L$$b10
000274036 7001_ $$00000-0002-4061-0837$$aTeunissen, Charlotte E$$b11
000274036 7001_ $$00000-0003-3234-912X$$aSchwarz, Claudia$$b12
000274036 7001_ $$00000-0003-2595-0224$$aGrittner, Ulrike$$b13
000274036 7001_ $$0P:(DE-2719)2812030$$aKörtvelyessy, Peter$$b14$$udzne
000274036 7001_ $$0P:(DE-2719)2812683$$aFlöel, Agnes$$b15$$eLast author
000274036 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14318$$gVol. 20, no. 12, p. 8684 - 8699$$n12$$p8684 - 8699$$tAlzheimer's and dementia$$v20$$x1552-5260$$y2024
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