TY  - JOUR
AU  - Göschel, Laura
AU  - Dell Orco, Andrea
AU  - Fillmer, Ariane
AU  - Aydin, Semiha
AU  - Ittermann, Bernd
AU  - Riemann, Layla
AU  - Lehmann, Sylvain
AU  - Cano, Stefan
AU  - Melin, Jeanette
AU  - Pendrill, Leslie
AU  - Hoede, Patty L
AU  - Teunissen, Charlotte E
AU  - Schwarz, Claudia
AU  - Grittner, Ulrike
AU  - Körtvelyessy, Peter
AU  - Flöel, Agnes
TI  - Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS.
JO  - Alzheimer's and dementia
VL  - 20
IS  - 12
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2025-00017
SP  - 8684 - 8699
PY  - 2024
AB  - Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)-derived measurements in Alzheimer's disease (AD) remain unclear.In a study population (n = 127) of healthy older adults and patients within the AD continuum, we examined associations between longitudinal plasma amyloid beta 42/40 ratio, tau phosphorylated at threonine 181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and 7T structural and functional MR imaging and spectroscopy using linear mixed models.Increases in both p-tau181 and GFAP showed the strongest associations to 7T MR-derived measurements, particularly with decreasing parietal cortical thickness, decreasing connectivity of the salience network, and increasing neuroinflammation as determined by MR spectroscopy (MRS) myo-inositol.Both plasma p-tau181 and GFAP appear to reflect disease progression, as indicated by 7T MR-derived brain changes which are not limited to areas known to be affected by tau pathology and neuroinflammation measured by MRS myo-inositol, respectively.This study leverages high-resolution 7T magnetic resonance (MR) imaging and MR spectroscopy (MRS) for Alzheimer's disease (AD) plasma biomarker insights. Tau phosphorylated at threonine 181 (p-tau181) and glial fibrillary acidic protein (GFAP) showed the largest changes over time, particularly in the AD group. p-tau181 and GFAP are robust in reflecting 7T MR-based changes in AD. The strongest associations were for frontal/parietal MR changes and MRS neuroinflammation.
KW  - Humans
KW  - Alzheimer Disease: blood
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: diagnostic imaging
KW  - tau Proteins: blood
KW  - Female
KW  - Longitudinal Studies
KW  - Male
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Biomarkers: blood
KW  - Magnetic Resonance Spectroscopy
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Amyloid beta-Peptides: blood
KW  - Phosphorylation
KW  - Disease Progression
KW  - Middle Aged
KW  - Neurofilament Proteins: blood
KW  - 7 Tesla (Other)
KW  - Alzheimer's disease (Other)
KW  - NeuroMET Memory Metric (Other)
KW  - amyloid beta 42/40 (Other)
KW  - blood‐based biomarkers (Other)
KW  - functional magnetic resonance imaging (Other)
KW  - glial fibrillary acidic protein (Other)
KW  - magnetic resonance imaging (Other)
KW  - magnetic resonance spectroscopy (Other)
KW  - memory (Other)
KW  - mild cognitive impairment (Other)
KW  - neurofilament light chain (Other)
KW  - plasma biomarkers (Other)
KW  - subjective cognitive decline (Other)
KW  - tau phosphorylated at threonine 181 (Other)
KW  - tau Proteins (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39558898
C2  - pmc:PMC11667506
DO  - DOI:10.1002/alz.14318
UR  - https://pub.dzne.de/record/274036
ER  -