% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Tu:274042,
      author       = {Tu, Jiaxin Cindy and Millar, Peter R and Strain, Jeremy F
                      and Eck, Andrew and Adeyemo, Babatunde and Snyder, Abraham Z
                      and Daniels, Alisha and Karch, Celeste and Huey, Edward D
                      and McDade, Eric and Day, Gregory S and Yakushev, Igor and
                      Hassenstab, Jason and Morris, John and Llibre-Guerra, Jorge
                      J and Ibanez, Laura and Jucker, Mathias and Mendez, Patricio
                      Chrem and Perrin, Richard J and Benzinger, Tammie L S and
                      Jack, Clifford R and Betzel, Richard and Ances, Beau M and
                      Eggebrecht, Adam T and Gordon, Brian A and Wheelock, Muriah
                      D},
      collaboration = {Network, Dominantly Inherited Alzheimer},
      title        = {{I}ncreasing hub disruption parallels dementia severity in
                      autosomal dominant {A}lzheimer's disease.},
      journal      = {Network neuroscience},
      volume       = {8},
      number       = {4},
      issn         = {2472-1751},
      address      = {Cambridge, MA},
      publisher    = {The MIT Press},
      reportid     = {DZNE-2025-00023},
      pages        = {1265 - 1290},
      year         = {2024},
      abstract     = {Hub regions in the brain, recognized for their roles in
                      ensuring efficient information transfer, are vulnerable to
                      pathological alterations in neurodegenerative conditions,
                      including Alzheimer's disease (AD). Computational
                      simulations and animal experiments have hinted at the theory
                      of activity-dependent degeneration as the cause of this hub
                      vulnerability. However, two critical issues remain
                      unresolved. First, past research has not clearly
                      distinguished between two scenarios: hub regions facing a
                      higher risk of connectivity disruption (targeted attack) and
                      all regions having an equal risk (random attack). Second,
                      human studies offering support for activity-dependent
                      explanations remain scarce. We refined the hub disruption
                      index to demonstrate a hub disruption pattern in functional
                      connectivity in autosomal dominant AD that aligned with
                      targeted attacks. This hub disruption is detectable even in
                      preclinical stages, 12 years before the expected symptom
                      onset and is amplified alongside symptomatic progression.
                      Moreover, hub disruption was primarily tied to regional
                      differences in global connectivity and sequentially followed
                      changes observed in amyloid-beta positron emission
                      tomography cortical markers, consistent with the
                      activity-dependent degeneration explanation. Taken together,
                      our findings deepen the understanding of brain network
                      organization in neurodegenerative diseases and could be
                      instrumental in refining diagnostic and targeted therapeutic
                      strategies for AD in the future.},
      keywords     = {Alzheimer’s disease (Other) / Biomarker (Other) /
                      Functional connectivity (Other) / Hubs (Other) /
                      Neurodegeneration (Other)},
      cin          = {AG Jucker},
      ddc          = {610},
      cid          = {I:(DE-2719)1210001},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39735502},
      pmc          = {pmc:PMC11674321},
      doi          = {10.1162/netn_a_00395},
      url          = {https://pub.dzne.de/record/274042},
}