TY  - JOUR
AU  - Barba, Lorenzo
AU  - Gaetani, Lorenzo
AU  - Sperandei, Silvia
AU  - Di Sabatino, Elena
AU  - Abu-Rumeileh, Samir
AU  - Halbgebauer, Steffen
AU  - Oeckl, Patrick
AU  - Steinacker, Petra
AU  - Parnetti, Lucilla
AU  - Di FIlippo, Massimiliano
AU  - Otto, Markus
TI  - CSF synaptic biomarkers and cognitive impairment in multiple sclerosis.
JO  - Journal of neurology
VL  - 272
IS  - 1
SN  - 0367-004X
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2025-00026
SP  - 85
PY  - 2024
AB  - People with multiple sclerosis (PwMS) experience various degrees of cognitive impairment (CI). Synaptic dysfunction may contribute to CI in PwMS but cerebrospinal fluid (CSF) synaptic biomarkers are unexplored in MS.To assess the role of CSF synaptosomal-associated protein 25 (SNAP-25), β-synuclein, neurogranin and neurofilament light chain protein (NfL) in patients with early relapsing MS with and without CI.We measured CSF SNAP-25, β-synuclein, and neurogranin in 48 untreated PwMS and 50 controls with other neurological diseases (ONDs) and tested their associations with neuropsychological and MRI data.CSF synaptic protein levels did not discriminate between MS subjects and patients with ONDs, with only SNAP-25 values being slightly increased in MS (p = 0.009). CSF synaptic markers were positively correlated with each other and with CSF NfL. Moreover, lower biomarker levels were found to be correlated with longer disease duration and lower brain volumes (especially of the thalamus). Moreover, we found significantly lower CSF SNAP-25 (p = 0.025), β-synuclein (p = 0.044), and neurogranin (p = 0.007) levels in PwMS with vs. without domain-specific cognitive impairment.Lower CSF synaptic biomarker levels were found in PwMS with longer disease duration and lower brain volumes and may identify PwMS at risk of CI.
KW  - Humans
KW  - Female
KW  - Male
KW  - Synaptosomal-Associated Protein 25: cerebrospinal fluid
KW  - Cognitive Dysfunction: cerebrospinal fluid
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: diagnosis
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Neurogranin: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Adult
KW  - Middle Aged
KW  - Neurofilament Proteins: cerebrospinal fluid
KW  - Multiple Sclerosis, Relapsing-Remitting: cerebrospinal fluid
KW  - Multiple Sclerosis, Relapsing-Remitting: complications
KW  - Multiple Sclerosis, Relapsing-Remitting: diagnostic imaging
KW  - Magnetic Resonance Imaging
KW  - alpha-Synuclein: cerebrospinal fluid
KW  - Multiple Sclerosis: cerebrospinal fluid
KW  - Multiple Sclerosis: complications
KW  - Multiple Sclerosis: diagnostic imaging
KW  - Brain: diagnostic imaging
KW  - Beta-synuclein (Other)
KW  - CSF (Other)
KW  - Cognitive impairment (Other)
KW  - MS (Other)
KW  - Neurogranin (Other)
KW  - SNAP-25 (Other)
KW  - Synaptosomal-Associated Protein 25 (NLM Chemicals)
KW  - Neurogranin (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - SNAP25 protein, human (NLM Chemicals)
KW  - alpha-Synuclein (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39708160
C2  - pmc:PMC11663154
DO  - DOI:10.1007/s00415-024-12851-x
UR  - https://pub.dzne.de/record/274045
ER  -