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@ARTICLE{Barba:274045,
      author       = {Barba, Lorenzo and Gaetani, Lorenzo and Sperandei, Silvia
                      and Di Sabatino, Elena and Abu-Rumeileh, Samir and
                      Halbgebauer, Steffen and Oeckl, Patrick and Steinacker,
                      Petra and Parnetti, Lucilla and Di FIlippo, Massimiliano and
                      Otto, Markus},
      title        = {{CSF} synaptic biomarkers and cognitive impairment in
                      multiple sclerosis.},
      journal      = {Journal of neurology},
      volume       = {272},
      number       = {1},
      issn         = {0367-004X},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2025-00026},
      pages        = {85},
      year         = {2024},
      abstract     = {People with multiple sclerosis (PwMS) experience various
                      degrees of cognitive impairment (CI). Synaptic dysfunction
                      may contribute to CI in PwMS but cerebrospinal fluid (CSF)
                      synaptic biomarkers are unexplored in MS.To assess the role
                      of CSF synaptosomal-associated protein 25 (SNAP-25),
                      β-synuclein, neurogranin and neurofilament light chain
                      protein (NfL) in patients with early relapsing MS with and
                      without CI.We measured CSF SNAP-25, β-synuclein, and
                      neurogranin in 48 untreated PwMS and 50 controls with other
                      neurological diseases (ONDs) and tested their associations
                      with neuropsychological and MRI data.CSF synaptic protein
                      levels did not discriminate between MS subjects and patients
                      with ONDs, with only SNAP-25 values being slightly increased
                      in MS (p = 0.009). CSF synaptic markers were positively
                      correlated with each other and with CSF NfL. Moreover, lower
                      biomarker levels were found to be correlated with longer
                      disease duration and lower brain volumes (especially of the
                      thalamus). Moreover, we found significantly lower CSF
                      SNAP-25 (p = 0.025), β-synuclein (p = 0.044), and
                      neurogranin (p = 0.007) levels in PwMS with vs. without
                      domain-specific cognitive impairment.Lower CSF synaptic
                      biomarker levels were found in PwMS with longer disease
                      duration and lower brain volumes and may identify PwMS at
                      risk of CI.},
      keywords     = {Humans / Female / Male / Synaptosomal-Associated Protein
                      25: cerebrospinal fluid / Cognitive Dysfunction:
                      cerebrospinal fluid / Cognitive Dysfunction: etiology /
                      Cognitive Dysfunction: diagnosis / Cognitive Dysfunction:
                      diagnostic imaging / Neurogranin: cerebrospinal fluid /
                      Biomarkers: cerebrospinal fluid / Adult / Middle Aged /
                      Neurofilament Proteins: cerebrospinal fluid / Multiple
                      Sclerosis, Relapsing-Remitting: cerebrospinal fluid /
                      Multiple Sclerosis, Relapsing-Remitting: complications /
                      Multiple Sclerosis, Relapsing-Remitting: diagnostic imaging
                      / Magnetic Resonance Imaging / alpha-Synuclein:
                      cerebrospinal fluid / Multiple Sclerosis: cerebrospinal
                      fluid / Multiple Sclerosis: complications / Multiple
                      Sclerosis: diagnostic imaging / Brain: diagnostic imaging /
                      Beta-synuclein (Other) / CSF (Other) / Cognitive impairment
                      (Other) / MS (Other) / Neurogranin (Other) / SNAP-25 (Other)
                      / Synaptosomal-Associated Protein 25 (NLM Chemicals) /
                      Neurogranin (NLM Chemicals) / Biomarkers (NLM Chemicals) /
                      Neurofilament Proteins (NLM Chemicals) / neurofilament
                      protein L (NLM Chemicals) / SNAP25 protein, human (NLM
                      Chemicals) / alpha-Synuclein (NLM Chemicals)},
      cin          = {Clinical Study Center (Ulm) / AG Öckl},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077 / I:(DE-2719)5000073},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39708160},
      pmc          = {pmc:PMC11663154},
      doi          = {10.1007/s00415-024-12851-x},
      url          = {https://pub.dzne.de/record/274045},
}